Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aat0474 |
Microglia and early brain development: An intimate journey | |
Thion, Morgane S.1; Ginhoux, Florent2,3; Garel, Sonia1 | |
2018-10-12 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 362期号:6411页码:185-189 |
文章类型 | Review |
语种 | 英语 |
国家 | France; Singapore; Peoples R China |
英文摘要 | Cross-talk between the nervous and immune systems has been well described in the context of adult physiology and disease. Recent advances in our understanding of immune cell ontogeny have revealed a notable interplay between neurons and microglia during the prenatal and postnatal emergence of functional circuits. This Review focuses on the brain, where the early symbiotic relationship between microglia and neuronal cells critically regulates wiring, contributes to sex-specific differences in neural circuits, and relays crucial information from the periphery, including signals derived from the microbiota. These observations underscore the importance of studying neurodevelopment as part of a broader framework that considers nervous system interactions with microglia in a whole-body context. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000447337200044 |
WOS关键词 | CEREBRAL-CORTEX ; KEY ROLE ; DISEASE ; CONNECTIVITY ; MICE ; MYELINOGENESIS ; MACROPHAGES ; HOMEOSTASIS ; MATURATION ; PHENOTYPES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/199821 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.PSL Univ Paris, Ecole Normale Super, IBENS, CNRS,INSERM, F-75005 Paris, France; 2.ASTAR, Singapore Immunol Network SIgN, 8A Biomed Grove,IMMUNOS Bldg 3-4, Biopolis 138648, Singapore; 3.Shanghai Jiao Tong Univ, Shanghai Inst Immunol, Sch Med, 280 South Chongqing Rd, Shanghai 200025, Peoples R China |
推荐引用方式 GB/T 7714 | Thion, Morgane S.,Ginhoux, Florent,Garel, Sonia. Microglia and early brain development: An intimate journey[J]. SCIENCE,2018,362(6411):185-189. |
APA | Thion, Morgane S.,Ginhoux, Florent,&Garel, Sonia.(2018).Microglia and early brain development: An intimate journey.SCIENCE,362(6411),185-189. |
MLA | Thion, Morgane S.,et al."Microglia and early brain development: An intimate journey".SCIENCE 362.6411(2018):185-189. |
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