Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aat6806 |
Dynamic DNA methylation: In the right place at the right time | |
Luo, Chongyuan1,2; Hajkova, Petra3,4; Ecker, Joseph R.1,2 | |
2018-09-28 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 361期号:6409页码:1336-1340 |
文章类型 | Review |
语种 | 英语 |
国家 | USA; England |
英文摘要 | The classical model of cytosine DNA methylation (the presence of 5-methylcytosine, 5mC) regulation depicts this covalent modification as a stable repressive regulator of promoter activity. However, whole-genome analysis of 5mC reveals widespread tissue-and cell type-specific patterns and pervasive dynamics during mammalian development. Here we review recent findings that delineate 5mC functions in developmental stages and diverse genomic compartments as well as discuss the molecular mechanisms that connect transcriptional regulation and 5mC. Beyond the newly appreciated dynamics, regulatory roles for 5mC have been suggested in new biological contexts, such as learning and memory or aging. The use of new single-cell measurement techniques and precise editing tools will enable functional analyses of 5mC in gene expression, clarifying its role in various biological processes. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000446142200041 |
WOS关键词 | TRANSCRIPTION FACTORS ; RETT-SYNDROME ; CELL ; EPIGENOME ; BINDING ; GENOME ; MECHANISMS ; GENE ; ACTIVATION ; TRANSITION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/199682 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Salk Inst Biol Studies, Genom Anal Lab, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA; 2.Salk Inst Biol Studies, Howard Hughes Med Inst, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA; 3.MRC London Inst Med Sci LMS, Du Cane Rd, London W12 0NN, England; 4.Imperial Coll London, ICS, Fac Med, Du Cane Rd, London W12 0NN, England |
推荐引用方式 GB/T 7714 | Luo, Chongyuan,Hajkova, Petra,Ecker, Joseph R.. Dynamic DNA methylation: In the right place at the right time[J]. SCIENCE,2018,361(6409):1336-1340. |
APA | Luo, Chongyuan,Hajkova, Petra,&Ecker, Joseph R..(2018).Dynamic DNA methylation: In the right place at the right time.SCIENCE,361(6409),1336-1340. |
MLA | Luo, Chongyuan,et al."Dynamic DNA methylation: In the right place at the right time".SCIENCE 361.6409(2018):1336-1340. |
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