Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aat5236 |
A gut-brain neural circuit for nutrient sensory transduction | |
Kaelberer, Melanie Maya1; Buchanan, Kelly L.2; Klein, Marguerita E.1; Barth, Bradley B.3; Montoya, Marcia M.3; Shen, Xiling3; Bohorquez, Diego V.1,4,5 | |
2018-09-21 | |
发表期刊 | SCIENCE
![]() |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 361期号:6408页码:1219-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | The brain is thought to sense gut stimuli only via the passive release of hormones. This is because no connection has been described between the vagus and the putative gut epithelial sensor cell-the enteroendocrine cell. However, these electrically excitable cells contain several features of epithelial transducers. Using a mouse model, we found that enteroendocrine cells synapse with vagal neurons to transduce gut luminal signals inmilliseconds by using glutamate as a neurotransmitter. These synaptically connected enteroendocrine cells are referred to henceforth as neuropod cells. The neuroepithelial circuit they form connects the intestinal lumen to the brainstem in one synapse, opening a physical conduit for the brain to sense gut stimuli with the temporal precision and topographical resolution of a synapse. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000445152500033 |
WOS关键词 | GLUCAGON-LIKE PEPTIDE-1 ; ENTEROCHROMAFFIN CELLS ; IN-VIVO ; SINGLE ; RAT ; GLUTAMATE ; NEURONS ; NEUROTRANSMITTER ; ORGANIZATION ; SECRETION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/199625 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Duke Univ, Dept Med, Durham, NC 27708 USA; 2.Duke Univ, Sch Med, Durham, NC USA; 3.Duke Univ, Dept Biomed Engn, Durham, NC 27706 USA; 4.Duke Univ, Dept Neurobiol, Durham, NC 27708 USA; 5.Duke Univ, Duke Inst Brain Sci, Durham, NC 27708 USA |
推荐引用方式 GB/T 7714 | Kaelberer, Melanie Maya,Buchanan, Kelly L.,Klein, Marguerita E.,et al. A gut-brain neural circuit for nutrient sensory transduction[J]. SCIENCE,2018,361(6408):1219-+. |
APA | Kaelberer, Melanie Maya.,Buchanan, Kelly L..,Klein, Marguerita E..,Barth, Bradley B..,Montoya, Marcia M..,...&Bohorquez, Diego V..(2018).A gut-brain neural circuit for nutrient sensory transduction.SCIENCE,361(6408),1219-+. |
MLA | Kaelberer, Melanie Maya,et al."A gut-brain neural circuit for nutrient sensory transduction".SCIENCE 361.6408(2018):1219-+. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论