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DOI | 10.1126/science.aat6904 |
Recurrent cortical circuits implement concentration-invariant odor coding | |
Bolding, Kevin A.; Franks, Kevin M. | |
2018-09-14 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 361期号:6407页码:1088-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Animals rely on olfaction to find food, attract mates, and avoid predators. To support these behaviors, they must be able to identify odors across different odorant concentrations. The neural circuit operations that implement this concentration invariance remain unclear. We found that despite concentration-dependence in the olfactory bulb (OB), representations of odor identity were preserved downstream, in the piriform cortex (PCx). The OB cells responding earliest after inhalation drove robust responses in sparse subsets of PCx neurons. Recurrent collateral connections broadcast their activation across the PCx, recruiting global feedback inhibition that rapidly truncated and suppressed cortical activity for the remainder of the sniff, discounting the impact of slower, concentration-dependent OB inputs. Eliminating recurrent collateral output amplified PCx odor responses rendered the cortex steeply concentration-dependent and abolished concentration-invariant identity decoding. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000444513300033 |
WOS关键词 | MAMMALIAN OLFACTORY-BULB ; PIRIFORM CORTEX ; IN-VIVO ; SPIKE LATENCIES ; REPRESENTATIONS ; SPARSE ; ACTIVATION ; INHIBITION ; NETWORK ; OUTPUT |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/199582 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | Duke Univ, Med Sch, Dept Neurobiol, Durham, NC 27708 USA |
推荐引用方式 GB/T 7714 | Bolding, Kevin A.,Franks, Kevin M.. Recurrent cortical circuits implement concentration-invariant odor coding[J]. SCIENCE,2018,361(6407):1088-+. |
APA | Bolding, Kevin A.,&Franks, Kevin M..(2018).Recurrent cortical circuits implement concentration-invariant odor coding.SCIENCE,361(6407),1088-+. |
MLA | Bolding, Kevin A.,et al."Recurrent cortical circuits implement concentration-invariant odor coding".SCIENCE 361.6407(2018):1088-+. |
条目包含的文件 | 条目无相关文件。 |
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