Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aat6777 |
Serotype-specific immunity explains the incidence of diseases caused by human enteroviruses | |
Pons-Salort, Margarita; Grassly, Nicholas C. | |
2018-08-24 | |
发表期刊 | SCIENCE
![]() |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 361期号:6404页码:800-803 |
文章类型 | Article |
语种 | 英语 |
国家 | England |
英文摘要 | Human enteroviruses are a major cause of neurological and other diseases. More than 100 serotypes are known that exhibit unexplained complex patterns of incidence, from regular cycles to more irregular patterns, and new emergences. Using 15 years of surveillance data from Japan (2000-2014) and a stochastic transmission model with accurate demography, we show that acquired serotype-specific immunity can explain the diverse patterns of 18 of the 20 most common serotypes (including Coxsackieviruses, Echoviruses, and Enterovirus-A71). The remaining two serotypes required a change in viral characteristics, including an increase in pathogenicity for Coxsackievirus-A6, which is consistent with its recent global rise in incidence. On the basis of our findings, we are able to predict outbreaks 2 years ahead of time (2015-2016). These results have implications for the impact of vaccines under development. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000442828700045 |
WOS关键词 | MOUTH-DISEASE ; POLIOVIRUS ; POPULATION ; CHILDREN ; FOOT ; HAND |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/199424 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | Imperial Coll London, Dept Infect Dis Epidemiol, St Marys Campus, London W2 1PG, England |
推荐引用方式 GB/T 7714 | Pons-Salort, Margarita,Grassly, Nicholas C.. Serotype-specific immunity explains the incidence of diseases caused by human enteroviruses[J]. SCIENCE,2018,361(6404):800-803. |
APA | Pons-Salort, Margarita,&Grassly, Nicholas C..(2018).Serotype-specific immunity explains the incidence of diseases caused by human enteroviruses.SCIENCE,361(6404),800-803. |
MLA | Pons-Salort, Margarita,et al."Serotype-specific immunity explains the incidence of diseases caused by human enteroviruses".SCIENCE 361.6404(2018):800-803. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论