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DOI | 10.1126/science.aam5794 |
Mixed tailing by TENT4A and TENT4B shields mRNA from rapid deadenylation | |
Lim, Jaechul1,2,3; Kim, Dongwan1,2; Lee, Young-suk1,2; Ha, Minju1,2; Lee, Mihye1,2; Yeo, Jinah1,2; Chang, Hyeshik1,2; Song, Jaewon1,2; Ahn, Kwangseog1,2; Kim, V. Narry1,2 | |
2018-08-17 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 361期号:6403页码:701-+ |
文章类型 | Article |
语种 | 英语 |
国家 | South Korea; USA |
英文摘要 | RNA tails play integral roles in the regulation of messenger RNA (mRNA) translation and decay. Guanylation of the poly(A) tail was discovered recently, yet the enzymology and function remain obscure. Here we identify TENT4A (PAPD7) and TENT4B (PAPD5) as the enzymes responsible for mRNA guanylation. Purified TENT4 proteins generate amixed poly(A) tail with intermittent non-adenosine residues, the most common of which is guanosine. A single guanosine residue is sufficient to impede the deadenylase CCR4-NOT complex, which trims the tail and exposes guanosine at the 3' end. Consistently, depletion of TENT4A and TENT4B leads to a decrease in mRNA half-life and abundance in cells. Thus, TENT4A and TENT4B produce a mixed tail that shields mRNA from rapid deadenylation. Our study unveils the role of mixed tailing and expands the complexity of posttranscriptional gene regulation. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000442818200044 |
WOS关键词 | NONCANONICAL POLY(A) POLYMERASE ; DEGRADATION ; COMPLEX ; OLIGOURIDYLATION ; IDENTIFICATION ; URIDYLATION ; ADENYLATION ; TURNOVER ; PROTEINS ; DISEASE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/199390 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Inst for Basic Sci Korea, Ctr RNA Res, Seoul 151742, South Korea; 2.Seoul Natl Univ, Sch Biol Sci, Seoul 151742, South Korea; 3.Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06510 USA |
推荐引用方式 GB/T 7714 | Lim, Jaechul,Kim, Dongwan,Lee, Young-suk,et al. Mixed tailing by TENT4A and TENT4B shields mRNA from rapid deadenylation[J]. SCIENCE,2018,361(6403):701-+. |
APA | Lim, Jaechul.,Kim, Dongwan.,Lee, Young-suk.,Ha, Minju.,Lee, Mihye.,...&Kim, V. Narry.(2018).Mixed tailing by TENT4A and TENT4B shields mRNA from rapid deadenylation.SCIENCE,361(6403),701-+. |
MLA | Lim, Jaechul,et al."Mixed tailing by TENT4A and TENT4B shields mRNA from rapid deadenylation".SCIENCE 361.6403(2018):701-+. |
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