Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aap7714 |
Ancient convergent losses of Paraoxonase 1 yield potential risks for modern marine mammals | |
Meyer, Wynn K.1; Jamison, Jerrica2; Richter, Rebecca3; Woods, Stacy E.4,11; Partha, Raghavendran1; Kowalczyk, Amanda1; Kronk, Charles2; Chikina, Maria1; Bonde, Robert K.5; Crocker, Daniel E.6; Gaspard, Joseph7; Lanyon, Janet M.8; Marsillach, Judit3; Furlong, Clement E.3,9; Clark, Nathan L.1,10 | |
2018-08-10 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 361期号:6402页码:591-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Australia |
英文摘要 | Mammals diversified by colonizing drastically different environments, with each transition yielding numerous molecular changes, including losses of protein function. Though not initially deleterious, these losses could subsequently carry deleterious pleiotropic consequences. We have used phylogenetic methods to identify convergent functional losses across independent marine mammal lineages. In one extreme case, Paraoxonase 1 (PON1) accrued lesions in all marine lineages, while remaining intact in all terrestrial mammals. These lesions coincide with PON1 enzymatic activity loss in marine species' blood plasma. This convergent loss is likely explained by parallel shifts in marine ancestors' lipid metabolism and/or bloodstream oxidative environment affecting PON1's role in fatty acid oxidation. PON1 loss also eliminates marine mammals' main defense against neurotoxicity from specific man-made organophosphorus compounds, implying potential risks in modern environments. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000441202700035 |
WOS关键词 | ORGANOPHOSPHORUS COMPOUNDS ; REGRESSIVE EVOLUTION ; PESTICIDES ; PON1 |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/199338 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Pittsburgh, Dept Computat & Syst Biol, Pittsburgh, PA 15260 USA; 2.Univ Pittsburgh, Dietrich Sch Arts & Sci, Pittsburgh, PA USA; 3.Univ Washington, Dept Med, Div Med Genet, Seattle, WA 98195 USA; 4.Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA; 5.US Geol Survey, Wetland & Aquat Res Ctr, Gainesville, FL USA; 6.Sonoma State Univ, Dept Biol, Rohnert Pk, CA 94928 USA; 7.Pittsburgh Zoo & PPG Aquarium, Pittsburgh, PA USA; 8.Univ Queensland, Sch Biol Sci, St Lucia, Qld 4072, Australia; 9.Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA; 10.Univ Pittsburgh, Pittsburgh Ctr Evolutionary Biol & Med, Pittsburgh, PA 15260 USA; 11.Nat Resources Def Council, Washington, DC USA |
推荐引用方式 GB/T 7714 | Meyer, Wynn K.,Jamison, Jerrica,Richter, Rebecca,et al. Ancient convergent losses of Paraoxonase 1 yield potential risks for modern marine mammals[J]. SCIENCE,2018,361(6402):591-+. |
APA | Meyer, Wynn K..,Jamison, Jerrica.,Richter, Rebecca.,Woods, Stacy E..,Partha, Raghavendran.,...&Clark, Nathan L..(2018).Ancient convergent losses of Paraoxonase 1 yield potential risks for modern marine mammals.SCIENCE,361(6402),591-+. |
MLA | Meyer, Wynn K.,et al."Ancient convergent losses of Paraoxonase 1 yield potential risks for modern marine mammals".SCIENCE 361.6402(2018):591-+. |
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