Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aap9331 |
Lacteal junction zippering protects against diet-induced obesity | |
Zhang, Feng1; Zarkada, Georgia1; Han, Jinah1; Li, Jinyu1; Dubrac, Alexandre1; Ola, Roxana1,2; Genet, Gael1; Boye, Kevin1; Michon, Pauline1,3; Kunzel, Steffen E.1; Camporez, Joao Paulo4; Singh, Abhishek K.5,6,7; Fong, Guo-Hua8; Simons, Michael1; Tso, Patrick9; Fernandez-Hernando, Carlos5,6,7; Shulman, Gerald I.4,10; Sessa, William C.11; Eichmann, Anne1,3,10 | |
2018-08-10 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 361期号:6402页码:599-603 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Romania; France |
英文摘要 | Excess dietary lipid uptake causes obesity, a major global health problem. Enterocyte-absorbed lipids are packaged into chylomicrons, which enter the bloodstream through intestinal lymphatic vessels called lacteals. Here, we show that preventing lacteal chylomicron uptake by inducible endothelial genetic deletion of Neuropilin1 (Nrpl) and Vascular endothelial growth factor receptor 1 (Vegfr1; also known as Flt1) renders mice resistant to diet-induced obesity. Absence of NRP1 and FLT1 receptors increased VEGF-A bioavailability and signaling through VEGFR2, inducing lacteal junction zippering and chylomicron malabsorption. Restoring permeable lacteal junctions by VEGFR2 and vascular endothelial (VE)-cadherin signaling inhibition rescued chylomicron transport in the mutant mice. Zippering of lacteal junctions by disassembly of cytoskeletal VE-cadherin anchors prevented chylomicron uptake in wild-type mice. These data suggest that lacteal junctions may be targets for preventing dietary fat uptake. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000441202700037 |
WOS关键词 | ENDOTHELIAL-CELLS ; VEGF-C ; LIPOPROTEINS ; MECHANISMS ; TRANSPORT ; GROWTH ; CHYLOMICRONS ; ANGIOGENESIS ; INFLAMMATION ; INTEGRITY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/199337 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Yale Univ, Sch Med, Cardiovasc Res Ctr, 333 Cedar St, New Haven, CT 06510 USA; 2.Univ Transylvania, Dept Basic Prevent & Clin Sci, Brasov 500019, Romania; 3.Paris Cardiovasc Res Ctr, INSERM, U970, F-75015 Paris, France; 4.Yale Univ, Sch Med, Dept Internal Med, New Haven, CT 06510 USA; 5.Yale Univ, Sch Med, Vasc Biol & Therapeut Program, Dept Community Med, New Haven, CT USA; 6.Yale Univ, Sch Med, Vasc Biol & Therapeut Program, Dept Pathol, New Haven, CT USA; 7.Yale Univ, Sch Med, Integrat Cell Signaling & Neurobiol Metab Program, New Haven, CT USA; 8.Univ Connecticut, Hlth Ctr, Dept Cell Biol, Farmington, CT 06030 USA; 9.Univ Cincinnati, Metab Dis Inst, Dept Pathol & Lab Med, Cincinnati, OH 45237 USA; 10.Yale Univ, Sch Med, Dept Cellular & Mol Physiol, New Haven, CT 06510 USA; 11.Yale Univ, Sch Med, Dept Pharmacol, Vasc Biol & Therapeut Program, New Haven, CT 06510 USA |
推荐引用方式 GB/T 7714 | Zhang, Feng,Zarkada, Georgia,Han, Jinah,et al. Lacteal junction zippering protects against diet-induced obesity[J]. SCIENCE,2018,361(6402):599-603. |
APA | Zhang, Feng.,Zarkada, Georgia.,Han, Jinah.,Li, Jinyu.,Dubrac, Alexandre.,...&Eichmann, Anne.(2018).Lacteal junction zippering protects against diet-induced obesity.SCIENCE,361(6402),599-603. |
MLA | Zhang, Feng,et al."Lacteal junction zippering protects against diet-induced obesity".SCIENCE 361.6402(2018):599-603. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论