Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aan5835 |
Here, there, and everywhere: The importance of ER membrane contact sites | |
Wu, Haoxi1; Carvalho, Pedro2; Voeltz, Gia K.1 | |
2018-08-03 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 361期号:6401页码:CP15-U70 |
文章类型 | Review |
语种 | 英语 |
国家 | USA; England |
英文摘要 | Our textbook image of organelles has changed. Instead of revealing isolated cellular compartments, the picture now emerging shows organelles as largely interdependent structures that can communicate through membrane contact sites (MCSs). MCSs are sites where opposing organelles are tethered but do not fuse. MCSs provide a hybrid location where the tool kits of two different organelles can work together to perform vital cellular functions, such as lipid and ion transfer, signaling, and organelle division. Here, we focus on MCSs involving the endoplasmic reticulum (ER), an organelle forming an extensive network of cisternae and tubules. We highlight how the dynamic ER network regulates a plethora of cellular processes through MCSs with various organelles and with the plasma membrane. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000440627300031 |
WOS关键词 | DEPENDENT ANION CHANNEL ; REGULATES CA2+ DYNAMICS ; ENDOPLASMIC-RETICULUM ; MITOCHONDRIAL FISSION ; MECHANISTIC INSIGHTS ; PHOSPHATIDIC-ACID ; CRYSTAL-STRUCTURE ; LIPID DROPLETS ; LATE ENDOSOMES ; CRAC CHANNELS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/199297 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USA; 2.Univ Oxford, Sir William Dunn Sch Pathol, Oxford, England |
推荐引用方式 GB/T 7714 | Wu, Haoxi,Carvalho, Pedro,Voeltz, Gia K.. Here, there, and everywhere: The importance of ER membrane contact sites[J]. SCIENCE,2018,361(6401):CP15-U70. |
APA | Wu, Haoxi,Carvalho, Pedro,&Voeltz, Gia K..(2018).Here, there, and everywhere: The importance of ER membrane contact sites.SCIENCE,361(6401),CP15-U70. |
MLA | Wu, Haoxi,et al."Here, there, and everywhere: The importance of ER membrane contact sites".SCIENCE 361.6401(2018):CP15-U70. |
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