Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aat2058 |
Lectins modulate the microbiota of social amoebae | |
Dinh, Christopher1,2; Farinholt, Timothy1; Hirose, Shigenori1; Zhuchenko, Olga1; Kuspa, Adam1,2 | |
2018-07-27 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 361期号:6400页码:402-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | The social amoeba Dictyostelium discoideum maintains a microbiome during multicellular development: bacteria are carried in migrating slugs and as endosymbionts within amoebae and spores. Bacterial carriage and endosymbiosis are induced by the secreted lectin discoidin I that binds bacteria, protects them from extracellular killing, and alters their retention within amoebae. This altered handling of bacteria also occurs with bacteria coated by plant lectins and leads to DNA transfer from bacteria to amoebae. Thus, lectins alter the cellular response of D. discoideum to bacteria to establish the amoebae's microbiome. Mammalian cells can also maintain intracellular bacteria when presented with bacteria coated with lectins, so heterologous lectins may induce endosymbiosis in animals. Our results suggest that endogenous or environmental lectins may influence microbiome homeostasis across eukaryotic phylogeny. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000439923700043 |
WOS关键词 | DICTYOSTELIUM-DISCOIDEUM ; KLEBSIELLA-PNEUMONIAE ; GROWING-CELLS ; MACROPHAGES ; BACTERIA ; LECTINOPHAGOCYTOSIS ; POLYSACCHARIDE ; PURIFICATION ; ADHESION ; AFFINITY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/199247 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Baylor Coll Med, Verna & Marrs McLean Dept Biochem & Mol Biol, Houston, TX 77030 USA; 2.Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA |
推荐引用方式 GB/T 7714 | Dinh, Christopher,Farinholt, Timothy,Hirose, Shigenori,et al. Lectins modulate the microbiota of social amoebae[J]. SCIENCE,2018,361(6400):402-+. |
APA | Dinh, Christopher,Farinholt, Timothy,Hirose, Shigenori,Zhuchenko, Olga,&Kuspa, Adam.(2018).Lectins modulate the microbiota of social amoebae.SCIENCE,361(6400),402-+. |
MLA | Dinh, Christopher,et al."Lectins modulate the microbiota of social amoebae".SCIENCE 361.6400(2018):402-+. |
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