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DOI | 10.1126/science.aar7462 |
Dual-spindle formation in zygotes keeps parental genomes apart in early mammalian embryos | |
Reichmann, Judith1; Nijmeijer, Bianca1; Hossain, M. Julius1; Eguren, Manuel1; Schneider, Isabell1; Politi, Antonio Z.1; Roberti, M. Julia1; Hufnagel, Lars1; Hiiragi, Takashi2; Ellenberg, Jan1 | |
2018-07-13 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 361期号:6398页码:189-193 |
文章类型 | Article |
语种 | 英语 |
国家 | Germany |
英文摘要 | At the beginning of mammalian life, the genetic material from each parent meets when the fertilized egg divides. It was previously thought that a single microtubule spindle is responsible for spatially combining the two genomes and then segregating them to create the two-cell embryo. We used light-sheet microscopy to show that two bipolar spindles form in the zygote and then independently congress the maternal and paternal genomes. These two spindles aligned their poles before anaphase but kept the parental genomes apart during the first cleavage. This spindle assembly mechanism provides a potential rationale for erroneous divisions into more than two blastomeric nuclei observed in mammalian zygotes and reveals the mechanism behind the observation that parental genomes occupy separate nuclear compartments in the two-cell embryo. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000438449200048 |
WOS关键词 | MULTINUCLEATED BLASTOMERES ; EPIGENETIC ASYMMETRY ; PATERNAL GENOME ; MOUSE EMBRYOS ; HETEROCHROMATIN ; OOCYTES ; FERTILIZATION ; ORGANIZATION ; MITOSIS ; SPERM |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/199154 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.European Mol Biol Lab, Cell Biol & Biophys Unit, Meyerhofstr 1, D-69117 Heidelberg, Germany; 2.European Mol Biol Lab, Dev Biol Unit, Meyerhofstr 1, D-69117 Heidelberg, Germany |
推荐引用方式 GB/T 7714 | Reichmann, Judith,Nijmeijer, Bianca,Hossain, M. Julius,et al. Dual-spindle formation in zygotes keeps parental genomes apart in early mammalian embryos[J]. SCIENCE,2018,361(6398):189-193. |
APA | Reichmann, Judith.,Nijmeijer, Bianca.,Hossain, M. Julius.,Eguren, Manuel.,Schneider, Isabell.,...&Ellenberg, Jan.(2018).Dual-spindle formation in zygotes keeps parental genomes apart in early mammalian embryos.SCIENCE,361(6398),189-193. |
MLA | Reichmann, Judith,et al."Dual-spindle formation in zygotes keeps parental genomes apart in early mammalian embryos".SCIENCE 361.6398(2018):189-193. |
条目包含的文件 | 条目无相关文件。 |
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