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DOI | 10.1126/science.aat6205 |
Tandem catalysis for asymmetric coupling of ethylene and enynes to functionalized cyclobutanes | |
Pagar, Vinayak Vishnu; RajanBabu, T. V. | |
2018-07-06 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 361期号:6397页码:68-72 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Transformation of simple precursors into structurally complex cyclobutanes, present in many biologically important natural products and pharmaceuticals, is of considerable interest in medicinal chemistry. Starting from 1,3-enynes and ethylene, both exceptionally inexpensive starting materials, we report a cobalt-catalyzed route to vinylcyclobutenes, as well as the further enantioselective addition of ethylene to these products to form complex cyclobutanes with all-carbon quaternary centers. These reactions can proceed in discrete stages or in a tandem fashion to achieve three highly selective carbon-carbon bond formations in one pot using a single chiral cobalt catalyst. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000437467100062 |
WOS关键词 | CONSTRUCTION ; 1,3-DIENES ; ALCOHOLS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/199071 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | Ohio State Univ, Dept Chem & Biochem, Columbus, OH 43210 USA |
推荐引用方式 GB/T 7714 | Pagar, Vinayak Vishnu,RajanBabu, T. V.. Tandem catalysis for asymmetric coupling of ethylene and enynes to functionalized cyclobutanes[J]. SCIENCE,2018,361(6397):68-72. |
APA | Pagar, Vinayak Vishnu,&RajanBabu, T. V..(2018).Tandem catalysis for asymmetric coupling of ethylene and enynes to functionalized cyclobutanes.SCIENCE,361(6397),68-72. |
MLA | Pagar, Vinayak Vishnu,et al."Tandem catalysis for asymmetric coupling of ethylene and enynes to functionalized cyclobutanes".SCIENCE 361.6397(2018):68-72. |
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