Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aao1157 |
A molecular mechanism for choosing alcohol over an alternative reward | |
Augier, Eric1; Barbier, Estelle1; Dulman, Russell S.2; Licheri, Valentina3; Augier, Gaelle1; Domi, Esi1; Barchiesi, Riccardo1; Farris, Sean4; Natt, Daniel1; Mayfield, R. Dayne4; Adermark, Louise3; Heilig, Markus1 | |
2018-06-22 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 360期号:6395页码:1321-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Sweden; USA |
英文摘要 | Alcohol addiction leads to increased choice of alcohol over healthy rewards. We established an exclusive choice procedure in which similar to 15% of outbred rats chose alcohol over a high-value reward. These animals displayed addiction-like traits, including high motivation to obtain alcohol and pursuit of this drug despite adverse consequences. Expression of the g-aminobutyric acid (GABA) transporter GAT-3 was selectively decreased within the amygdala of alcohol-choosing rats, whereas a knockdown of this transcript reversed choice preference of rats that originally chose a sweet solution over alcohol. GAT-3 expression was selectively decreased in the central amygdala of alcohol-dependent people compared to those who died of unrelated causes. Impaired GABA clearance within the amygdala contributes to alcohol addiction, appears to translate between species, and may offer targets for new pharmacotherapies for treating this disorder. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000436040600037 |
WOS关键词 | GENE-EXPRESSION ; ANIMAL-MODELS ; DRUG-USE ; ADDICTION ; BEHAVIOR ; COCAINE ; ANXIETY ; BRAIN ; RATS ; TRANSPORTERS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198951 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Linkoping Univ, IKE, Ctr Social & Affect Neurosci, S-58183 Linkoping, Sweden; 2.Univ Illinois, Dept Psychiat, Ctr Alcohol Res Epigenet, Chicago, IL 60612 USA; 3.Univ Goteborg, Sahlgrenska Acad, Dept Psychiat & Neurochem, S-41390 Gothenburg, Sweden; 4.Univ Texas Austin, Waggoner Ctr Alcohol & Addict Res, Austin, TX 78712 USA |
推荐引用方式 GB/T 7714 | Augier, Eric,Barbier, Estelle,Dulman, Russell S.,et al. A molecular mechanism for choosing alcohol over an alternative reward[J]. SCIENCE,2018,360(6395):1321-+. |
APA | Augier, Eric.,Barbier, Estelle.,Dulman, Russell S..,Licheri, Valentina.,Augier, Gaelle.,...&Heilig, Markus.(2018).A molecular mechanism for choosing alcohol over an alternative reward.SCIENCE,360(6395),1321-+. |
MLA | Augier, Eric,et al."A molecular mechanism for choosing alcohol over an alternative reward".SCIENCE 360.6395(2018):1321-+. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论