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DOI | 10.1126/science.aar5304 |
Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope | |
Imkeller, Katharina1,2; Scally, Stephen W.3; Bosch, Alexandre3; Marti, Gemma Pidelaserra1,2; Costa, Giulia4; Triller, Gianna1; Murugan, Rajagopal1; Renna, Valerio5; Jumaa, Hassan5; Kremsner, Peter G.6,7; Sim, B. Kim Lee8; Hoffman, Stephen L.8; Mordmueller, Benjamin6,7; Levashina, Elena A.4; Julien, Jean-Philippe3,9,10; Wardemann, Hedda1 | |
2018-06-22 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 360期号:6395页码:1358-1362 |
文章类型 | Article |
语种 | 英语 |
国家 | Germany; Canada; USA |
英文摘要 | Affinity maturation selects B cells expressing somatically mutated antibody variants with improved antigen-binding properties to protect from invading pathogens. We determined the molecular mechanism underlying the clonal selection and affinity maturation of human B cells expressing protective antibodies against the circumsporozoite protein of the malaria parasite Plasmodium falciparum (PfCSP). We show in molecular detail that the repetitive nature of PfCSP facilitates direct homotypic interactions between two PfCSP repeat-bound monoclonal antibodies, thereby improving antigen affinity and B cell activation. These data provide a mechanistic explanation for the strong selection of somatic mutations that mediate homotypic antibody interactions after repeated parasite exposure in humans. Our findings demonstrate a different mode of antigen-mediated affinity maturation to improve antibody responses to PfCSP and presumably other repetitive antigens. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000436040600046 |
WOS关键词 | PLASMODIUM-FALCIPARUM ; MALARIA PARASITE ; CIRCUMSPOROZOITE PROTEIN ; MONOCLONAL-ANTIBODIES ; SURFACE-ANTIGEN ; INFECTION ; SPOROZOITE ; VACCINE ; REPERTOIRE ; SEQUENCE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198943 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.German Canc Res Inst, Cell Immunol B, Heidelberg, Germany; 2.Heidelberg Univ, Fac Biosci, Heidelberg, Germany; 3.Hosp Sick Children, Res Inst, Program Mol Med, Toronto, ON, Canada; 4.Max Planck Inst Infect Biol, Vector Biol Unit, Berlin, Germany; 5.Univ Med Ctr Ulm, Inst Immunol, Ulm, Germany; 6.Univ Tubingen, Inst Trop Med, Partner Site, Tubingen, Germany; 7.Univ Tubingen, German Ctr Infect Res, Partner Site, Tubingen, Germany; 8.Sanaria, Rockville, MD USA; 9.Univ Toronto, Dept Biochem, Toronto, ON, Canada; 10.Univ Toronto, Dept Immunol, Toronto, ON, Canada |
推荐引用方式 GB/T 7714 | Imkeller, Katharina,Scally, Stephen W.,Bosch, Alexandre,et al. Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope[J]. SCIENCE,2018,360(6395):1358-1362. |
APA | Imkeller, Katharina.,Scally, Stephen W..,Bosch, Alexandre.,Marti, Gemma Pidelaserra.,Costa, Giulia.,...&Wardemann, Hedda.(2018).Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope.SCIENCE,360(6395),1358-1362. |
MLA | Imkeller, Katharina,et al."Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope".SCIENCE 360.6395(2018):1358-1362. |
条目包含的文件 | 条目无相关文件。 |
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