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DOI | 10.1126/science.aao4908 |
Unresolved endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases | |
Pommier, Arnaud1; Anaparthy, Naishitha1,2; Memos, Nicoletta1; Kelley, Z. Larkin3; Gouronnec, Alizee1; Yan, Ran1; Auffray, Cedric4; Albrengues, Jean1; Egeblad, Mikala1; Iacobuzio-Donahue, Christine A.5; Lyons, Scott K.1; Fearon, Douglas T.1,3,6 | |
2018-06-15 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 360期号:6394页码:1202-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; France; England |
英文摘要 | The majority of patients with pancreatic ductal adenocarcinoma (PDA) develop metastatic disease after resection of their primary tumor. We found that livers from patients and mice with PDA harbor single disseminated cancer cells (DCCs) lacking expression of cytokeratin 19 (CK19) and major histocompatibility complex class I (MHCI). We created a mouse model to determine how these DCCs develop. Intraportal injection of immunogenic PDA cells into preimmunized mice seeded livers only with single, nonreplicating DCCs that were CK19-and MHCI-. The DCCs exhibited an endoplasmic reticulum (ER) stress response but paradoxically lacked both inositol-requiring enzyme 1a activation and expression of the spliced form of transcription factor XBP1 (XBP1s). Inducible expression of XBP1s in DCCs, in combination with T cell depletion, stimulated the outgrowth of macrometastatic lesions that expressed CK19 and MHCI. Thus, unresolved ER stress enables DCCs to escape immunity and establish latent metastases. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000435360400046 |
WOS关键词 | UNFOLDED PROTEIN RESPONSE ; MICROMETASTATIC CARCINOMA-CELLS ; MHC CLASS-I ; DUCTAL ADENOCARCINOMA ; TUMOR-CELLS ; T-CELLS ; INHIBITION ; EXPRESSION ; DORMANCY ; IMMUNOTHERAPY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198901 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA; 2.SUNY Stony Brook, Dept Mol & Cellular Biol, Stony Brook, NY 11794 USA; 3.Weill Cornell Med, New York, NY 10065 USA; 4.Paris Descartes Univ, CNRS, Inst Cochin, INSERM,UMR8104,U1016, F-75014 Paris, France; 5.Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA; 6.Univ Cambridge, Canc Res UK Cambridge Inst, Robinson Way, Cambridge CB2 0RE, England |
推荐引用方式 GB/T 7714 | Pommier, Arnaud,Anaparthy, Naishitha,Memos, Nicoletta,et al. Unresolved endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases[J]. SCIENCE,2018,360(6394):1202-+. |
APA | Pommier, Arnaud.,Anaparthy, Naishitha.,Memos, Nicoletta.,Kelley, Z. Larkin.,Gouronnec, Alizee.,...&Fearon, Douglas T..(2018).Unresolved endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases.SCIENCE,360(6394),1202-+. |
MLA | Pommier, Arnaud,et al."Unresolved endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases".SCIENCE 360.6394(2018):1202-+. |
条目包含的文件 | 条目无相关文件。 |
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