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DOI | 10.1126/science.aar2578 |
Normative brain size variation and brain shape diversity in humans | |
Reardon, P. K.1,2,3; Seidlitz, Jakob1,4; Vandekar, Simon5; Liu, Siyuan1; Patel, Raihaan6,7; Park, Min Tae M.6,8; Alexander-Bloch, Aaron9; Clasen, Liv S.1; Blumenthal, Jonathan D.1; Lalonde, Francois M.1; Giedd, Jay N.10; Gur, Ruben C.11; Gur, Raquel E.11; Lerch, Jason P.12; Chakravarty, M. Mallar6,7; Satterthwaite, Theodore D.11; Shinohara, Russell T.5; Raznahan, Armin1 | |
2018-06-15 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 360期号:6394页码:1222-1226 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; England; Canada |
英文摘要 | Brain size variation over primate evolution and human development is associated with shifts in the proportions of different brain regions. Individual brain size can vary almost twofold among typically developing humans, but the consequences of this for brain organization remain poorly understood. Using in vivo neuroimaging data from more than 3000 individuals, we find that larger human brains show greater areal expansion in distributed frontoparietal cortical networks and related subcortical regions than in limbic, sensory, and motor systems. This areal redistribution recapitulates cortical remodeling across evolution, manifests by early childhood in humans, and is linked to multiple markers of heightened metabolic cost and neuronal connectivity. Thus, human brain shape is systematically coupled to naturally occurring variations in brain size through a scaling map that integrates spatiotemporally diverse aspects of neurobiology. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000435360400051 |
WOS关键词 | CEREBRAL-CORTEX ; ORGANIZATION ; NETWORK ; EXPANSION ; EVOLUTION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198898 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.NIMH, Dev Neurogen Unit, NIH, Bethesda, MD 20892 USA; 2.Univ Oxford, Dept Physiol Anat & Genet, Oxford, England; 3.Vagelos Coll Phys & Surg, New York, NY USA; 4.Univ Cambridge, Dept Psychiat, Cambridge, England; 5.Univ Penn, Dept Biostat Epidemiol & Informat, Philadelphia, PA 19104 USA; 6.Douglas Mental Hlth Univ Inst, Cerebral Imaging Ctr, Montreal, PQ, Canada; 7.McGill Univ, Dept Biol & Biomed Engn, Montreal, PQ, Canada; 8.Western Univ, Schulich Sch Med & Dent, London, ON, Canada; 9.Yale Univ, Dept Psychiat, New Haven, CT 06520 USA; 10.Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA; 11.Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA; 12.Hosp Sick Children, Mouse Imaging Ctr, Toronto, ON, Canada |
推荐引用方式 GB/T 7714 | Reardon, P. K.,Seidlitz, Jakob,Vandekar, Simon,et al. Normative brain size variation and brain shape diversity in humans[J]. SCIENCE,2018,360(6394):1222-1226. |
APA | Reardon, P. K..,Seidlitz, Jakob.,Vandekar, Simon.,Liu, Siyuan.,Patel, Raihaan.,...&Raznahan, Armin.(2018).Normative brain size variation and brain shape diversity in humans.SCIENCE,360(6394),1222-1226. |
MLA | Reardon, P. K.,et al."Normative brain size variation and brain shape diversity in humans".SCIENCE 360.6394(2018):1222-1226. |
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