Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aat1780 |
Near-atomic model of microtubule-tau interactions | |
Kellogg, Elizabeth H.1,2,3; Hejab, Nisreen M. A.3; Poepsel, Simon1,2; Downing, Kenneth H.3; DiMaio, Frank4,5; Nogales, Eva1,2,3,6 | |
2018-06-15 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 360期号:6394页码:1242-1245 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Tau is a developmentally regulated axonal protein that stabilizes and bundles microtubules (MTs). Its hyperphosphorylation is thought to cause detachment from MTs and subsequent aggregation into fibrils implicated in Alzheimer's disease. It is unclear which tau residues are crucial for tau-MT interactions, where tau binds on MTs, and how it stabilizes them. We used cryo-electron microscopy to visualize different tau constructs on MTs and computational approaches to generate atomic models of tau-tubulin interactions. The conserved tubulin-binding repeats within tau adopt similar extended structures along the crest of the protofilament, stabilizing the interface between tubulin dimers. Our structures explain the effect of phosphorylation on MT affinity and lead to a model of tau repeats binding in tandem along protofilaments, tethering together tubulin dimers and stabilizing polymerization interfaces. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000435360400056 |
WOS关键词 | ALZHEIMERS-DISEASE ; DYNAMIC INSTABILITY ; BINDING DOMAINS ; TUBULIN DIMERS ; PROTEIN ; PHOSPHORYLATION ; FILAMENTS ; FTDP-17 ; MOTIFS ; SITES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198890 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Calif Berkeley, Inst QB3, Berkeley, CA 94720 USA; 2.Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA; 3.Lawrence Berkeley Natl Lab, Div Mol Biophys & Integrated Bioimaging, Berkeley, CA 94720 USA; 4.Univ Washington, Dept Biochem, Seattle, WA 98195 USA; 5.Inst Prot Design, Seattle, WA 98195 USA; 6.Univ Calif Berkeley, Howard Hughes Med Inst, Berkeley, CA 94720 USA |
推荐引用方式 GB/T 7714 | Kellogg, Elizabeth H.,Hejab, Nisreen M. A.,Poepsel, Simon,et al. Near-atomic model of microtubule-tau interactions[J]. SCIENCE,2018,360(6394):1242-1245. |
APA | Kellogg, Elizabeth H.,Hejab, Nisreen M. A.,Poepsel, Simon,Downing, Kenneth H.,DiMaio, Frank,&Nogales, Eva.(2018).Near-atomic model of microtubule-tau interactions.SCIENCE,360(6394),1242-1245. |
MLA | Kellogg, Elizabeth H.,et al."Near-atomic model of microtubule-tau interactions".SCIENCE 360.6394(2018):1242-1245. |
条目包含的文件 | 条目无相关文件。 |
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