Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aar3819 |
Noninvasive blood tests for fetal development predict gestational age and preterm delivery | |
Ngo, Thuy T. M.1,2,3,11,12; Moufarrej, Mira N.1,2,3; Rasmussen, Marie-Louise H.4; Camunas-Soler, Joan1,2,3; Pan, Wenying1,2,3; Okamoto, Jennifer1,2,3; Neff, Norma F.1,2,3; Liu, Keli5; Wong, Ronald J.6; Downes, Katheryne7; Tibshirani, Robert5,8; Shaw, Gary M.6; Skotte, Line4; Stevenson, David K.6; Biggio, Joseph R.9; Elovitz, Michal A.7; Melbye, Mads4,10; Quake, Stephen R.1,2,3 | |
2018-06-08 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 360期号:6393页码:1133-1136 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Denmark |
英文摘要 | Noninvasive blood tests that provide information about fetal development and gestational age could potentially improve prenatal care. Ultrasound, the current gold standard, is not always affordable in low-resource settings and does not predict spontaneous preterm birth, a leading cause of infant death. In a pilot study of 31 healthy pregnant women, we found that measurement of nine cell-free RNA (cfRNA) transcripts in maternal blood predicted gestational age with comparable accuracy to ultrasound but at substantially lower cost. In a related study of 38 women (23 full-term and 15 preterm deliveries), all at elevated risk of delivering preterm, we identified seven cfRNA transcripts that accurately classified women who delivered preterm up to 2 months in advance of labor. These tests hold promise for prenatal care in both the developed and developing worlds, although they require validation in larger, blinded clinical trials. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000434635500050 |
WOS关键词 | LAST MENSTRUAL PERIOD ; SYSTEMATIC ANALYSIS ; ULTRASOUND ; EXPRESSION ; BIRTH ; CHILD |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198845 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA; 2.Stanford Univ, Dept Appl Phys, Stanford, CA 94305 USA; 3.Chan Zuckerberg Biohub, Stanford, CA 94305 USA; 4.Statens Serum Inst, Dept Epidemiol Res, DK-2300 Copenhagen, Denmark; 5.Stanford Univ, Dept Stat, Stanford, CA 94305 USA; 6.Stanford Univ, Dept Pediat, Sch Med, Stanford, CA 94305 USA; 7.Univ Penn, Sch fvledicine, Dept Obstet & Gynecol, Maternal & Child Hlth Res Ctr, Philadelphia, PA 19104 USA; 8.Stanford Univ, Sch Med, Dept Biomed Data Sci, Stanford, CA 94305 USA; 9.Univ Alabama Birmingham, Dept Obstet & Gynecol, Ctr Womens Reprod Hlth, Birmingham, AL 35294 USA; 10.Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA; 11.Oregon Hlth and Sci Univ, Canc Early Detect Adv Res Ctr, Knight Canc Inst, Portland, OR 97239 USA; 12.Oregon Hlth and Sci Univ, Dept Mol & Med Genet, Portland, OR 97239 USA |
推荐引用方式 GB/T 7714 | Ngo, Thuy T. M.,Moufarrej, Mira N.,Rasmussen, Marie-Louise H.,et al. Noninvasive blood tests for fetal development predict gestational age and preterm delivery[J]. SCIENCE,2018,360(6393):1133-1136. |
APA | Ngo, Thuy T. M..,Moufarrej, Mira N..,Rasmussen, Marie-Louise H..,Camunas-Soler, Joan.,Pan, Wenying.,...&Quake, Stephen R..(2018).Noninvasive blood tests for fetal development predict gestational age and preterm delivery.SCIENCE,360(6393),1133-1136. |
MLA | Ngo, Thuy T. M.,et al."Noninvasive blood tests for fetal development predict gestational age and preterm delivery".SCIENCE 360.6393(2018):1133-1136. |
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