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DOI | 10.1126/science.aar2625 |
Ancient genomes from Iceland reveal the making of a human population | |
Ebenesersdottir, S. Sunna1,2; Sandoval-Velasco, Marcela3; Gunnarsdottir, Ellen D.1,2; Jagadeesan, Anuradha1,2; Guomundsdottir, Valdis B.1,2; Thordardottir, Elisabet L.1,2; Einarsdottir, Margret S.1,2; Moore, Kristjan H. S.1; Sigurosson, Asgeir1; Magnusdottir, Droplaug N.1; Jonsson, Hakon1; Snorradottir, Steinunn1; Hovig, Eivind4,5,6; Moller, Pal4,7,8; Kockum, Ingrid9; Olsson, Tomas9; Alfredsson, Lars10; Hansen, Thomas F.11,12; Werge, Thomas11,13,14; Cavalleri, Gianpiero L.15; Gilbert, Edmund15; Lalueza-Fox, Carles16; Walser, Joew., III17,18; Kristjansdottir, Steinunn17,18; Gopalakrishnan, Shyam3; Arnadottir, Lilja17; Magnusson, Olafur P.1; Gilbert, M. Thomas P.3,19; Stefansson, Kari1,20; Helgason, Agnar1,2 | |
2018-06-01 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 360期号:6392页码:1028-1032 |
文章类型 | Article |
语种 | 英语 |
国家 | Iceland; Denmark; Norway; Germany; Sweden; Ireland; Spain |
英文摘要 | Opportunities to directly study the founding of a human population and its subsequent evolutionary history are rare. Using genome sequence data from 27 ancient Icelanders, we demonstrate that they are a combination of Norse, Gaelic, and admixed individuals. We further show that these ancient Icelanders are markedly more similar to their source populations in Scandinavia and the British-Irish Isles than to contemporary Icelanders, who have been shaped by 1100 years of extensive genetic drift. Finally, we report evidence of unequal contributions from the ancient founders to the contemporary Icelandic gene pool. These results provide detailed insights into the making of a human population that has proven extraordinarily useful for the discovery of genotype-phenotype associations. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000433574200045 |
WOS关键词 | HISTORY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198799 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.AMGEN Inc, DeCODE Genet, Reykjavik, Iceland; 2.Univ Iceland, Dept Anthropol, Reykjavik, Iceland; 3.Univ Copenhagen, Nat Hist Museum Denmark, Oster Voldgade 5-7, DK-1350 Copenhagen K, Denmark; 4.Oslo Univ Hosp, Inst Canc Res, Dept Tumor Biol, Oslo, Norway; 5.Oslo Univ Hosp, Inst Canc Genet & Informat, Oslo, Norway; 6.Univ Oslo, Dept Informat, Oslo, Norway; 7.Univ Witten Herdecke, Dept Human Med, Witten, Germany; 8.Oslo Univ Hosp, Dept Med Genet, Res Grp Inherited Canc, Oslo, Norway; 9.Karolinska Inst, Dept Clin Neurosci, Neuroimmunol Unit, Ctr Mol Med, Stockholm, Sweden; 10.Karolinska Inst, Inst Environm Med, Stockholm, Sweden; 11.Copenhagen Mental Hlth Serv, Inst Biol Psychiat, Copenhagen, Denmark; 12.Copenhagen Univ Hosp, Dept Neurol, Danish Headache Ctr, DK-2600 Glostrup, Denmark; 13.Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark; 14.iPSYCH, Lundbeck Fdn Initiat Integrat Psychiat Res, Copenhagen, Denmark; 15.Royal Coll Surgeons Ireland, Mol & Cellular Therapeut, 123 St Stephens Green, Dublin, Ireland; 16.Inst Biol Evolut UPF CSIC, Barcelona, Spain; 17.Natl Museum Iceland, Reykjavik, Iceland; 18.Univ Iceland, Dept Archaeol, Reykjavik, Iceland; 19.Norwegian Univ Sci & Techonol, Univ Museum, N-7491 Trondheim, Norway; 20.Univ Iceland, Fac Med, Reykjavik, Iceland |
推荐引用方式 GB/T 7714 | Ebenesersdottir, S. Sunna,Sandoval-Velasco, Marcela,Gunnarsdottir, Ellen D.,et al. Ancient genomes from Iceland reveal the making of a human population[J]. SCIENCE,2018,360(6392):1028-1032. |
APA | Ebenesersdottir, S. Sunna.,Sandoval-Velasco, Marcela.,Gunnarsdottir, Ellen D..,Jagadeesan, Anuradha.,Guomundsdottir, Valdis B..,...&Helgason, Agnar.(2018).Ancient genomes from Iceland reveal the making of a human population.SCIENCE,360(6392),1028-1032. |
MLA | Ebenesersdottir, S. Sunna,et al."Ancient genomes from Iceland reveal the making of a human population".SCIENCE 360.6392(2018):1028-1032. |
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