Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aar7432 |
mRNA structure determines specificity of a polyQ-driven phase separation | |
Langdon, Erin M.1; Qiu, Yupeng2; Niaki, Amirhossein Ghanbari2; McLaughlin, Grace A.1; Weidmann, Chase A.3; Gerbich, Therese M.1; Smith, Jean A.1; Crutchley, John M.1; Termini, Christina M.4; Weeks, Kevin M.3; Myong, Sua2; Gladfelter, Amy S.1,5 | |
2018-05-25 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 360期号:6391页码:922-927 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | RNA promotes liquid-liquid phase separation (LLPS) to build membraneless compartments in cells. How distinct molecular compositions are established and maintained in these liquid compartments is unknown. Here, we report that secondary structure allows messenger RNAs (mRNAs) to self-associate and determines whether an mRNA is recruited to or excluded from liquid compartments. The polyQ-protein Whi3 induces conformational changes in RNA structure and generates distinct molecular fluctuations depending on the RNA sequence. These data support a model in which structure-based, RNA-RNA interactions promote assembly of distinct droplets and protein-driven, conformational dynamics of the RNA maintain this identity. Thus, the shape of RNA can promote the formation and coexistence of the diverse array of RNA-rich liquid compartments found in a single cell. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000433039800052 |
WOS关键词 | PROTEIN ; WHI3 ; YEAST ; AGGREGATION ; TRANSITIONS ; DROPLETS ; CELLS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198736 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ North Carolina Chapel Hill, Dept Biol, Chapel Hill, NC 27599 USA; 2.Johns Hopkins Univ, Dept Biophys, Baltimore, MD 21218 USA; 3.Univ North Carolina Chapel Hill, Dept Chem, Chapel Hill, NC 27599 USA; 4.Univ Calif Los Angeles, Div Hematol Oncol, Dept Med, Los Angeles, CA 90095 USA; 5.Marine Biol Lab, Woods Hole, MA 02543 USA |
推荐引用方式 GB/T 7714 | Langdon, Erin M.,Qiu, Yupeng,Niaki, Amirhossein Ghanbari,et al. mRNA structure determines specificity of a polyQ-driven phase separation[J]. SCIENCE,2018,360(6391):922-927. |
APA | Langdon, Erin M..,Qiu, Yupeng.,Niaki, Amirhossein Ghanbari.,McLaughlin, Grace A..,Weidmann, Chase A..,...&Gladfelter, Amy S..(2018).mRNA structure determines specificity of a polyQ-driven phase separation.SCIENCE,360(6391),922-927. |
MLA | Langdon, Erin M.,et al."mRNA structure determines specificity of a polyQ-driven phase separation".SCIENCE 360.6391(2018):922-927. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论