GSTDTAP  > 地球科学
DOI10.1126/science.aar7432
mRNA structure determines specificity of a polyQ-driven phase separation
Langdon, Erin M.1; Qiu, Yupeng2; Niaki, Amirhossein Ghanbari2; McLaughlin, Grace A.1; Weidmann, Chase A.3; Gerbich, Therese M.1; Smith, Jean A.1; Crutchley, John M.1; Termini, Christina M.4; Weeks, Kevin M.3; Myong, Sua2; Gladfelter, Amy S.1,5
2018-05-25
发表期刊SCIENCE
ISSN0036-8075
EISSN1095-9203
出版年2018
卷号360期号:6391页码:922-927
文章类型Article
语种英语
国家USA
英文摘要

RNA promotes liquid-liquid phase separation (LLPS) to build membraneless compartments in cells. How distinct molecular compositions are established and maintained in these liquid compartments is unknown. Here, we report that secondary structure allows messenger RNAs (mRNAs) to self-associate and determines whether an mRNA is recruited to or excluded from liquid compartments. The polyQ-protein Whi3 induces conformational changes in RNA structure and generates distinct molecular fluctuations depending on the RNA sequence. These data support a model in which structure-based, RNA-RNA interactions promote assembly of distinct droplets and protein-driven, conformational dynamics of the RNA maintain this identity. Thus, the shape of RNA can promote the formation and coexistence of the diverse array of RNA-rich liquid compartments found in a single cell.


领域地球科学 ; 气候变化 ; 资源环境
收录类别SCI-E
WOS记录号WOS:000433039800052
WOS关键词PROTEIN ; WHI3 ; YEAST ; AGGREGATION ; TRANSITIONS ; DROPLETS ; CELLS
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
引用统计
文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/198736
专题地球科学
资源环境科学
气候变化
作者单位1.Univ North Carolina Chapel Hill, Dept Biol, Chapel Hill, NC 27599 USA;
2.Johns Hopkins Univ, Dept Biophys, Baltimore, MD 21218 USA;
3.Univ North Carolina Chapel Hill, Dept Chem, Chapel Hill, NC 27599 USA;
4.Univ Calif Los Angeles, Div Hematol Oncol, Dept Med, Los Angeles, CA 90095 USA;
5.Marine Biol Lab, Woods Hole, MA 02543 USA
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GB/T 7714
Langdon, Erin M.,Qiu, Yupeng,Niaki, Amirhossein Ghanbari,et al. mRNA structure determines specificity of a polyQ-driven phase separation[J]. SCIENCE,2018,360(6391):922-927.
APA Langdon, Erin M..,Qiu, Yupeng.,Niaki, Amirhossein Ghanbari.,McLaughlin, Grace A..,Weidmann, Chase A..,...&Gladfelter, Amy S..(2018).mRNA structure determines specificity of a polyQ-driven phase separation.SCIENCE,360(6391),922-927.
MLA Langdon, Erin M.,et al."mRNA structure determines specificity of a polyQ-driven phase separation".SCIENCE 360.6391(2018):922-927.
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