Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aas9315 |
An ingestible bacterial-electronic system to monitor gastrointestinal health | |
Mimee, Mark1,2; Nadeau, Phillip3,11; Hayward, Alison4,5; Carim, Sean2; Flanagan, Sarah3; Jerger, Logan2,6,7; Collins, Joy; McDonnell, Shane5; Swartwout, Richard3; Citorik, Robert J.1,2; Bulovic, Vladimir; Langer, Robert5,8; Traverso, Giovanni5,8,9; Chandrakasan, Anantha P.3; Lu, Timothy K.2,3,10 | |
2018-05-25 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 360期号:6391页码:915-918 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Biomolecular monitoring in the gastrointestinal tract could offer rapid, precise disease detection and management but is impeded by access to the remote and complex environment. Here, we present an ingestible micro-bio-electronic device (IMBED) for in situ biomolecular detection based on environmentally resilient biosensor bacteria and miniaturized luminescence readout electronics that wirelessly communicate with an external device. As a proof of concept, we engineer heme-sensitive probiotic biosensors and demonstrate accurate diagnosis of gastrointestinal bleeding in swine. Additionally, we integrate alternative biosensors to demonstrate modularity and extensibility of the detection platform. IMBEDs enable new opportunities for gastrointestinal biomarker discovery and could transform the management and diagnosis of gastrointestinal disease. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000433039800050 |
WOS关键词 | LAB-ON-CHIP ; MAMMALIAN GUT ; DIAGNOSTICS ; EVOLUTION ; SENSORS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198732 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.MIT, Microbiol Program, Cambridge, MA 02139 USA; 2.MIT, Synthet Biol Ctr, Cambridge, MA 02139 USA; 3.MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA; 4.MIT, Div Comparat Med, Cambridge, MA 02139 USA; 5.MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA; 6.MassGen Hosp Children, Div Pediat Gastroentrol Hepatol & Nutr, Dept Pediat, Boston, MA 02114 USA; 7.Harvard Med Sch, Boston, MA 02115 USA; 8.MIT, Dept Chem Engn, Cambridge, MA 02139 USA; 9.Brigham & Womens Hosp, Div Gastroenterol, Boston, MA 02115 USA; 10.MIT, Dept Biol Engn, Cambridge, MA 02139 USA; 11.Analog Devices Inc, Boston, MA 02110 USA |
推荐引用方式 GB/T 7714 | Mimee, Mark,Nadeau, Phillip,Hayward, Alison,et al. An ingestible bacterial-electronic system to monitor gastrointestinal health[J]. SCIENCE,2018,360(6391):915-918. |
APA | Mimee, Mark.,Nadeau, Phillip.,Hayward, Alison.,Carim, Sean.,Flanagan, Sarah.,...&Lu, Timothy K..(2018).An ingestible bacterial-electronic system to monitor gastrointestinal health.SCIENCE,360(6391),915-918. |
MLA | Mimee, Mark,et al."An ingestible bacterial-electronic system to monitor gastrointestinal health".SCIENCE 360.6391(2018):915-918. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论