Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aan5780 |
Metabolic regulation of transcription through compartmentalized NAD(+) biosynthesis | |
Ryu, Keun Woo1,2,3; Nandu, Tulip1,2; Kim, Jiyeon4; Challa, Sridevi1,2; DeBerardinis, Ralph J.4,5,6; Kraus, W. Lee1,2,3 | |
2018-05-11 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 360期号:6389 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | NAD(+) (nicotinamide adenine dinucleotide in its oxidized state) is an essential molecule for a variety of physiological processes. It is synthesized in distinct subcellular compartments by three different synthases (NMNAT-1, -2, and -3). We found that compartmentalized NAD(+) synthesis by NMNATs integrates glucose metabolism and adipogenic transcription during adipocyte differentiation. Adipogenic signaling rapidly induces cytoplasmic NMNAT-2, which competes with nuclear NMNAT-1 for the common substrate, nicotinamide mononucleotide, leading to a precipitous reduction in nuclear NAD(+) levels. This inhibits the catalytic activity of poly[adenosine diphosphate (ADP)-ribose] polymerase-1 (PARP-1), a NAD(+)-dependent enzyme that represses adipogenic transcription by ADP-ribosylating the adipogenic transcription factor C/EBPb. Reversal of PARP-1-mediated repression by NMNAT-2-mediated nuclear NAD(+) depletion in response to adipogenic signals drives adipogenesis. Thus, compartmentalized NAD(+) synthesis functions as an integrator of cellular metabolism and signal-dependent transcriptional programs. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000431790900034 |
WOS关键词 | GENE-EXPRESSION ; HISTONE ACETYLATION ; NUCLEAR ; POLY(ADP-RIBOSE) ; PARP-1 ; BINDING ; CELLS ; DIFFERENTIATION ; ADIPOGENESIS ; ENZYMES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198631 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Texas Southwestern Med Ctr Dallas, Cecil H & Ida Green Ctr Reprod Biol Sci, Lab Signaling & Gene Regulat, Dallas, TX 75390 USA; 2.Univ Texas Southwestern Med Ctr Dallas, Dept Obstet & Gynecol, Basic Res Div, Dallas, TX 75390 USA; 3.Univ Texas Southwestern Med Ctr Dallas, Grad Sch Biomed Sci, Program Genet Dev & Dis, Dallas, TX 75390 USA; 4.Univ Texas Southwestern Med Ctr Dallas, Childrens Med Ctr, Res Inst, Dallas, TX 75390 USA; 5.Univ Texas Southwestern Med Ctr Dallas, Dept Pediat, Dallas, TX 75390 USA; 6.Univ Texas Southwestern Med Ctr Dallas, McDermott Ctr Human Growth & Dev, Dallas, TX 75390 USA |
推荐引用方式 GB/T 7714 | Ryu, Keun Woo,Nandu, Tulip,Kim, Jiyeon,et al. Metabolic regulation of transcription through compartmentalized NAD(+) biosynthesis[J]. SCIENCE,2018,360(6389). |
APA | Ryu, Keun Woo,Nandu, Tulip,Kim, Jiyeon,Challa, Sridevi,DeBerardinis, Ralph J.,&Kraus, W. Lee.(2018).Metabolic regulation of transcription through compartmentalized NAD(+) biosynthesis.SCIENCE,360(6389). |
MLA | Ryu, Keun Woo,et al."Metabolic regulation of transcription through compartmentalized NAD(+) biosynthesis".SCIENCE 360.6389(2018). |
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