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DOI | 10.1126/science.aar6464 |
CORNICHON sorting and regulation of GLR channels underlie pollen tube Ca2+ homeostasis | |
Wudick, Michael M.1,2; Teresa Portes, Maria1,2; Michard, Erwan1,2; Rosas-Santiago, Paul3; Lizzio, Michael A.1; Oliveira Nunes, Custodio1,2; Campos, Claudia2; Cruz Damineli, Daniel Santa1; Carvalho, Joana C.2; Lima, Pedro T.2; Pantoja, Omar3; Feijo, Jose A.1,2 | |
2018-05-04 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 360期号:6388页码:533-536 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Portugal; Mexico |
英文摘要 | Compared to animals, evolution of plant calcium (Ca2+) physiology has led to a loss of proteins for influx and small ligand-operated control of cytosolic Ca2+, leaving many Ca2+ mechanisms unaccounted for. Here, we show a mechanism for sorting and activation of glutamate receptorlike channels (GLRs) by CORNICHON HOMOLOG (CNIH) proteins. Single mutants of pollenexpressed Arabidopsis thaliana GLRs (AtGLRs) showed growth and Ca2+ flux phenotypes expected for plasma membrane Ca2+ channels. However, higher-order mutants of AtGLR3.3 revealed phenotypes contradicting this assumption. These discrepancies could be explained by subcellular AtGLR localization, and we explored the implication of AtCNIHs in this sorting. We found that AtGLRs interact with AtCNIH pairs, yielding specific intracellular localizations. AtCNIHs further trigger AtGLR activity in mammalian cells without any ligand. These results reveal a regulatory mechanism underlying Ca2+ homeostasis by sorting and activation of AtGLRs by AtCNIHs. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000431351500046 |
WOS关键词 | RECEPTOR ; ARABIDOPSIS ; GROWTH ; MEMBRANE ; PLANTS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198569 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Maryland, Dept Cell Biol & Mol Genet, 0118 Biosci Res Bldg,4066 Campus Dr, College Pk, MD 20742 USA; 2.Inst Gulbenkian Ciencias, Rua Quinta Grande 6, P-2780156 Oeiras, Portugal; 3.Univ Nacl Autonoma Mexico, Inst Biotecnol, Cuernavaca, Morelos 62250, Mexico |
推荐引用方式 GB/T 7714 | Wudick, Michael M.,Teresa Portes, Maria,Michard, Erwan,et al. CORNICHON sorting and regulation of GLR channels underlie pollen tube Ca2+ homeostasis[J]. SCIENCE,2018,360(6388):533-536. |
APA | Wudick, Michael M..,Teresa Portes, Maria.,Michard, Erwan.,Rosas-Santiago, Paul.,Lizzio, Michael A..,...&Feijo, Jose A..(2018).CORNICHON sorting and regulation of GLR channels underlie pollen tube Ca2+ homeostasis.SCIENCE,360(6388),533-536. |
MLA | Wudick, Michael M.,et al."CORNICHON sorting and regulation of GLR channels underlie pollen tube Ca2+ homeostasis".SCIENCE 360.6388(2018):533-536. |
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