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DOI | 10.1126/science.aar5428 |
Structure of the nuclear exosome captured on a maturing preribosome | |
Schuller, Jan Michael1; Falk, Sebastian1; Fromm, Lisa2; Hurt, Ed2; Conti, Elena1 | |
2018-04-13 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 360期号:6385页码:219-222 |
文章类型 | Article |
语种 | 英语 |
国家 | Germany |
英文摘要 | The RNA exosome complex processes and degrades a wide range of transcripts, including ribosomal RNAs (rRNAs). We used cryo-electron microscopy to visualize the yeast nuclear exosome holocomplex captured on a precursor large ribosomal subunit (pre-60S) during 7S-to-5.8S rRNA processing. The cofactors of the nuclear exosome are sandwiched between the ribonuclease core complex (Exo-10) and the remodeled "foot" structure of the pre-60S particle, which harbors the 5.8S rRNA precursor. The exosome-associated helicase Mtr4 recognizes the preribosomal substrate by docking to specific sites on the 25S rRNA, captures the 3' extension of the 5.8S rRNA, and channels it toward Exo-10. The structure elucidates how the exosome forms a structural and functional unit together with its massive pre-60S substrate to process rRNA during ribosome maturation. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000429805400050 |
WOS关键词 | RNA EXOSOME ; RIBOSOMAL-RNA ; EUKARYOTIC EXOSOME ; CRYSTAL-STRUCTURE ; CENTRAL CHANNEL ; MTR4 HELICASE ; COMPLEX ; DEGRADATION ; BIOGENESIS ; REVEALS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198403 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.MPI Biochem, Dept Struct Cell Biol, Munich, Germany; 2.Heidelberg Univ, Biochem Ctr, Heidelberg, Germany |
推荐引用方式 GB/T 7714 | Schuller, Jan Michael,Falk, Sebastian,Fromm, Lisa,et al. Structure of the nuclear exosome captured on a maturing preribosome[J]. SCIENCE,2018,360(6385):219-222. |
APA | Schuller, Jan Michael,Falk, Sebastian,Fromm, Lisa,Hurt, Ed,&Conti, Elena.(2018).Structure of the nuclear exosome captured on a maturing preribosome.SCIENCE,360(6385),219-222. |
MLA | Schuller, Jan Michael,et al."Structure of the nuclear exosome captured on a maturing preribosome".SCIENCE 360.6385(2018):219-222. |
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