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DOI | 10.1126/science.aao2300 |
CRMP2-binding compound, edonerpic maleate, accelerates motor function recovery from brain damage | |
Abe, Hiroki1; Jitsuki, Susumu1; Nakajima, Waki1; Murata, Yumi2; Jitsuki-Takahashi, Aoi1; Katsuno, Yuki1; Tada, Hirobumi1; Sano, Akane1; Suyama, Kumiko1; Mochizuki, Nobuyuki1,3,4; Komori, Takashi1,3,4; Masuyama, Hitoshi1,3,4; Okuda, Tomohiro3,4; Goshima, Yoshio5; Higo, Noriyuki2; Takahashi, Takuya1 | |
2018-04-06 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 360期号:6384页码:50-57 |
文章类型 | Article |
语种 | 英语 |
国家 | Japan |
英文摘要 | Brain damage such as stroke is a devastating neurological condition that may severely compromise patient quality of life. No effective medication-mediated intervention to accelerate rehabilitation has been established. We found that a small compound, edonerpic maleate, facilitated experience-driven synaptic glutamate AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic-acid) receptor delivery and resulted in the acceleration of motor function recovery after motor cortex cryoinjury in mice in a training-dependent manner through cortical reorganization. Edonerpic bound to collapsin-response-mediator-protein 2 (CRMP2) and failed to augment recovery in CRMP2-deficient mice. Edonerpic maleate enhanced motor function recovery from internal capsule hemorrhage in nonhuman primates. Thus, edonerpic maleate, a neural plasticity enhancer, could be a clinically potent small compound with which to accelerate rehabilitation after brain damage. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000429263100044 |
WOS关键词 | AMPA RECEPTOR DELIVERY ; SPINAL-CORD-INJURY ; SYNAPTIC PLASTICITY ; SQUIRREL-MONKEYS ; ISCHEMIC INFARCT ; ACTIN DYNAMICS ; TRAFFICKING ; STROKE ; CORTEX ; REORGANIZATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198350 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Yokohama City Univ, Grad Sch Med, Dept Physiol, Yokohama, Kanagawa 2360004, Japan; 2.Natl Inst Adv Ind Sci & Technol, Human Informat Res Inst, Tsukuba 3058568, Japan; 3.Toyama Chem Co, Tokyo 1600023, Japan; 4.Fujifilm Corp, Tokyo 1070052, Japan; 5.Yokohama City Univ, Grad Sch Med, Dept Mol Pharmacol & Neurobiol, Yokohama, Kanagawa 2360004, Japan |
推荐引用方式 GB/T 7714 | Abe, Hiroki,Jitsuki, Susumu,Nakajima, Waki,et al. CRMP2-binding compound, edonerpic maleate, accelerates motor function recovery from brain damage[J]. SCIENCE,2018,360(6384):50-57. |
APA | Abe, Hiroki.,Jitsuki, Susumu.,Nakajima, Waki.,Murata, Yumi.,Jitsuki-Takahashi, Aoi.,...&Takahashi, Takuya.(2018).CRMP2-binding compound, edonerpic maleate, accelerates motor function recovery from brain damage.SCIENCE,360(6384),50-57. |
MLA | Abe, Hiroki,et al."CRMP2-binding compound, edonerpic maleate, accelerates motor function recovery from brain damage".SCIENCE 360.6384(2018):50-57. |
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