Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aar5078 |
Triggered recruitment of ESCRT machinery promotes endolysosomal repair | |
Skowyra, Michael L.; Schlesinger, Paul H.; Naismith, Teresa V.; Hanson, Phyllis I. | |
2018-04-06 | |
发表期刊 | SCIENCE
![]() |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 360期号:6384页码:49-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Endolysosomes can be damaged by diverse materials. Terminally damaged compartments are degraded by lysophagy, but pathways that repair salvageable organelles are poorly understood. Here we found that the endosomal sorting complex required for transport (ESCRT) machinery, known to mediate budding and fission on endolysosomes, also plays an essential role in their repair. ESCRTs were rapidly recruited to acutely injured endolysosomes through a pathway requiring calcium and ESCRT-activating factors that was independent of lysophagy. We used live-cell imaging to demonstrate that ESCRTs responded to small perforations in endolysosomal membranes and enabled compartments to recover from limited damage. Silica crystals that disrupted endolysosomes also triggered ESCRT recruitment. ESCRTs thus provide a defense against endolysosomal damage likely to be relevant in physiological and pathological contexts. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000429263100043 |
WOS关键词 | NUCLEAR-ENVELOPE RUPTURE ; LEUCINE METHYL-ESTER ; MEMBRANE REPAIR ; DAMAGED LYSOSOMES ; CELL-MIGRATION ; KIDNEY INJURY ; AUTOPHAGY ; MECHANISMS ; CONSEQUENCES ; GALECTIN-3 |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198341 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | Washington Univ, Sch Med, Dept Cell Biol & Physiol, St Louis, MO 63110 USA |
推荐引用方式 GB/T 7714 | Skowyra, Michael L.,Schlesinger, Paul H.,Naismith, Teresa V.,et al. Triggered recruitment of ESCRT machinery promotes endolysosomal repair[J]. SCIENCE,2018,360(6384):49-+. |
APA | Skowyra, Michael L.,Schlesinger, Paul H.,Naismith, Teresa V.,&Hanson, Phyllis I..(2018).Triggered recruitment of ESCRT machinery promotes endolysosomal repair.SCIENCE,360(6384),49-+. |
MLA | Skowyra, Michael L.,et al."Triggered recruitment of ESCRT machinery promotes endolysosomal repair".SCIENCE 360.6384(2018):49-+. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论