Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aar7112 |
Personalized vaccines for cancer immunotherapy | |
Sahin, Ugur1,2,3; Tureci, Ozlem4 | |
2018-03-23 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 359期号:6382页码:1355-1360 |
文章类型 | Review |
语种 | 英语 |
国家 | Germany |
英文摘要 | Cancer is characterized by an accumulation of genetic alterations. Somatic mutations can generate cancer-specific neoepitopes that are recognized by autologous T cells as foreign and constitute ideal cancer vaccine targets. Every tumor has its own unique composition of mutations, with only a small fraction shared between patients. Technological advances in genomics, data science, and cancer immunotherapy now enable the rapid mapping of the mutations within a genome, rational selection of vaccine targets, and on-demand production of a therapy customized to a patient's individual tumor. First-in-human clinical trials of personalized cancer vaccines have shown the feasibility, safety, and immunotherapeutic activity of targeting individual tumor mutation signatures. With vaccination development being promoted by emerging innovations of the digital age, vaccinating a patient with individual tumor mutations may become the first truly personalized treatment for cancer. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000428043600037 |
WOS关键词 | CYTOLYTIC T-LYMPHOCYTES ; EXOME ANALYSIS REVEALS ; MASS-SPECTROMETRY ; CTLA-4 BLOCKADE ; PD-1 BLOCKADE ; CELLS ; IMMUNITY ; MUTATIONS ; VECTORS ; TOOLS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198238 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Biopharmaceut New Technol BioNTech Corp, D-55131 Mainz, Germany; 2.Johannes Gutenberg Univ gGmbH, Univ Med Ctr, TRON Translat Oncol, D-55131 Mainz, Germany; 3.Johannes Gutenberg Univ Mainz, Univ Med Ctr, D-55131 Mainz, Germany; 4.CI3 Cluster Individualized Immunointervent eV, D-55131 Mainz, Germany |
推荐引用方式 GB/T 7714 | Sahin, Ugur,Tureci, Ozlem. Personalized vaccines for cancer immunotherapy[J]. SCIENCE,2018,359(6382):1355-1360. |
APA | Sahin, Ugur,&Tureci, Ozlem.(2018).Personalized vaccines for cancer immunotherapy.SCIENCE,359(6382),1355-1360. |
MLA | Sahin, Ugur,et al."Personalized vaccines for cancer immunotherapy".SCIENCE 359.6382(2018):1355-1360. |
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