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DOI | 10.1126/science.aag3048 |
Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging | |
Leeman, Dena S.1,2; Hebestreit, Katja1,9; Ruetz, Tyson1; Webb, Ashley E.1,10; McKay, Andrew1,3; Pollina, Elizabeth A.1,2,11; Dulken, Ben W.1,4; Zhao, Xiaoai1; Yeo, Robin W.1; Ho, Theodore T.5; Mahmoudi, Salah1; Devarajan, Keerthana1; Passegue, Emmanuelle5,12; Rando, Thomas A.6,7; Frydman, Judith1,8; Brunet, Anne1,2,7 | |
2018-03-16 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 359期号:6381页码:1277-1282 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | In the adult brain, the neural stem cell (NSC) pool comprises quiescent and activated populations with distinct roles. Transcriptomic analysis revealed that quiescent and activated NSCs exhibited differences in their protein homeostasis network. Whereas activated NSCs had active proteasomes, quiescent NSCs contained large lysosomes. Quiescent NSCs from young mice accumulated protein aggregates, and many of these aggregates were stored in large lysosomes. Perturbation of lysosomal activity in quiescent NSCs affected protein-aggregate accumulation and the ability of quiescent NSCs to activate. During aging, quiescent NSCs displayed defects in their lysosomes, increased accumulation of protein aggregates, and reduced ability to activate. Enhancement of the lysosome pathway in old quiescent NSCs cleared protein aggregates and ameliorated the ability of quiescent NSCs to activate, allowing them to regain a more youthful state. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000427504900046 |
WOS关键词 | AGE-RELATED-CHANGES ; AUTOPHAGY MAINTAINS ; BRAIN-INJURY ; NEUROGENESIS ; PROTEOSTASIS ; REVEALS ; POPULATION ; METABOLISM ; ELEGANS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198206 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Stanford Univ, Dept Genet, Stanford, CA 94305 USA; 2.Stanford Univ, Canc Biol Program, Stanford, CA 94305 USA; 3.Stanford Univ, Biol Grad Program, Stanford, CA 94305 USA; 4.Stanford Univ, Stanford Med Scientist Training Program, Stanford, CA 94305 USA; 5.Univ Calif San Francisco, Div Hematol & Oncol, Dept Med, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, San Francisco, CA 94143 USA; 6.Stanford Univ, Dept Neurol & Neurol Sci, Sch Med, Stanford, CA 94305 USA; 7.Stanford Univ, Glenn Ctr Biol Aging, Stanford, CA 94305 USA; 8.Stanford Univ, Dept Biol, Stanford, CA 94305 USA; 9.Verge Genom, San Francisco, CA 94103 USA; 10.Brown Univ, Dept Mol Biol Cell Biol & Biochem, Providence, RI 02903 USA; 11.Harvard Med Sch, Dept Neurobiol, Boston, MA 02115 USA; 12.Columbia Univ, Dept Genet & Dev, New York, NY 10032 USA |
推荐引用方式 GB/T 7714 | Leeman, Dena S.,Hebestreit, Katja,Ruetz, Tyson,et al. Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging[J]. SCIENCE,2018,359(6381):1277-1282. |
APA | Leeman, Dena S..,Hebestreit, Katja.,Ruetz, Tyson.,Webb, Ashley E..,McKay, Andrew.,...&Brunet, Anne.(2018).Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging.SCIENCE,359(6381),1277-1282. |
MLA | Leeman, Dena S.,et al."Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging".SCIENCE 359.6381(2018):1277-1282. |
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