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DOI | 10.1126/science.aal3589 |
Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development | |
Vainchtein, Ilia D.1; Chin, Gregory1; Cho, Frances S.5,7; Kelley, Kevin W.1; Miller, John G.1; Chien, Elliott C.1; Liddelow, Shane A.8,11,12; Nguyen, Phi T.1,6; Nakao-Inoue, Hiromi1; Dorman, Leah C.1,5; Akil, Omar3; Joshita, Satoru9,10; Barres, Ben A.8; Paz, Jeanne T.4,7; Molofsky, Ari B.2; Molofsky, Anna V.1 | |
2018-03-16 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 359期号:6381页码:1269-1273 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Japan |
英文摘要 | Neuronal synapse formation and remodeling are essential to central nervous system (CNS) development and are dysfunctional in neurodevelopmental diseases. Innate immune signals regulate tissue remodeling in the periphery, but how this affects CNS synapses is largely unknown. Here, we show that the interleukin-1 family cytokine interleukin-33 (IL-33) is produced by developing astrocytes and is developmentally required for normal synapse numbers and neural circuit function in the spinal cord and thalamus. We find that IL-33 signals primarily to microglia under physiologic conditions, that it promotes microglial synapse engulfment, and that it can drive microglial-dependent synapse depletion in vivo. These data reveal a cytokine-mediated mechanism required to maintain synapse homeostasis during CNS development. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000427504900044 |
WOS关键词 | INJURY ; BRAIN ; HOMEOSTASIS ; ROLES ; CNS ; INFLAMMATION ; RECOVERY ; IL-33 ; GLIA |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198205 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Calif San Francisco, Dept Psychiat, Weill Inst Neurosci, San Francisco, CA 94143 USA; 2.Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA; 3.Univ Calif San Francisco, Dept Otolaryngol, San Francisco, CA 94143 USA; 4.Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA; 5.Univ Calif San Francisco, Neurosci Grad Program, San Francisco, CA 94143 USA; 6.Univ Calif San Francisco, Biomed Sci Grad Program, San Francisco, CA 94143 USA; 7.Gladstone Inst Neurol Dis, San Francisco, CA 94158 USA; 8.Stanford Univ, Dept Neurobiol, Palo Alto, CA 94304 USA; 9.Shinshu Univ, Div Gastroenterol & Hepatol, Dept Med, Sch Med, Matsumoto, Nagano, Japan; 10.Shinshu Univ, Res Ctr Next Generat Med, Matsumoto, Nagano, Japan; 11.NYU, Neurosci Inst, Langone Med Sch, New York, NY USA; 12.NYU, Dept Neurosci & Physiol, Langone Med Sch, New York, NY USA |
推荐引用方式 GB/T 7714 | Vainchtein, Ilia D.,Chin, Gregory,Cho, Frances S.,et al. Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development[J]. SCIENCE,2018,359(6381):1269-1273. |
APA | Vainchtein, Ilia D..,Chin, Gregory.,Cho, Frances S..,Kelley, Kevin W..,Miller, John G..,...&Molofsky, Anna V..(2018).Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development.SCIENCE,359(6381),1269-1273. |
MLA | Vainchtein, Ilia D.,et al."Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development".SCIENCE 359.6381(2018):1269-1273. |
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