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DOI | 10.1126/science.aao4174 |
Defining the earliest step of cardiovascular lineage segregation by single-cell RNA-seq | |
Lescroart, Fabienne1; Wang, Xiaonan2,3; Lin, Xionghui1; Swedlund, Benjamin1; Gargouri, Souhir1; Sanchez-Danes, Adriana1; Moignard, Victoria2,3; Dubois, Christine1; Paulissen, Catherine1; Kinston, Sarah2,3; Gottgens, Berthold2,3; Blanpain, Cedric1,4 | |
2018-03-09 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 359期号:6380页码:1177-1181 |
文章类型 | Article |
语种 | 英语 |
国家 | Belgium; England |
英文摘要 | Mouse heart development arises from Mesp1-expressing cardiovascular progenitors (CPs) that are specified during gastrulation. The molecular processes that control early regional and lineage segregation of CPs have been unclear. We performed single-cell RNA sequencing of wild-type and Mesp1-null CPs in mice. We showed that populations of Mesp1 CPs are molecularly distinct and span the continuum between epiblast and later mesodermal cells, including hematopoietic progenitors. Single-cell transcriptome analysis of Mesp1-deficient CPs showed that Mesp1 is required for the exit from the pluripotent state and the induction of the cardiovascular gene expression program. We identified distinct populations of Mesp1 CPs that correspond to progenitors committed to different cell lineages and regions of the heart, identifying the molecular features associated with early lineage restriction and regional segregation of the heart at the early stage of mouse gastrulation. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000435215200001 |
WOS关键词 | PROGENITOR SPECIFICATION ; HEART DEVELOPMENT ; MAMMALIAN HEART ; MESP1 ; DIFFERENTIATION ; HETEROGENEITY ; RESTRICTION ; EXPRESSION ; REGULATOR ; REVEALS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198150 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Libre Bruxelles, Lab Stem Cells & Canc, B-1070 Brussels, Belgium; 2.Univ Cambridge, Cambridge Inst Med Res, Dept Haematol, Cambridge CB2 0XY, England; 3.Univ Cambridge, Wellcome & Med Res Council, Cambridge Stem Cell Inst, Cambridge, England; 4.Univ Libre Bruxelles, WELBIO, B-1070 Brussels, Belgium |
推荐引用方式 GB/T 7714 | Lescroart, Fabienne,Wang, Xiaonan,Lin, Xionghui,et al. Defining the earliest step of cardiovascular lineage segregation by single-cell RNA-seq[J]. SCIENCE,2018,359(6380):1177-1181. |
APA | Lescroart, Fabienne.,Wang, Xiaonan.,Lin, Xionghui.,Swedlund, Benjamin.,Gargouri, Souhir.,...&Blanpain, Cedric.(2018).Defining the earliest step of cardiovascular lineage segregation by single-cell RNA-seq.SCIENCE,359(6380),1177-1181. |
MLA | Lescroart, Fabienne,et al."Defining the earliest step of cardiovascular lineage segregation by single-cell RNA-seq".SCIENCE 359.6380(2018):1177-1181. |
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