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DOI | 10.1126/science.aao5902 |
Chemically induced proximity in biology and medicine | |
Stanton, Benjamin Z.1,2,3; Chory, Emma J.1,2,4; Crabtree, Gerald R.1,2,5 | |
2018-03-09 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 359期号:6380 |
文章类型 | Review |
语种 | 英语 |
国家 | USA |
英文摘要 | Proximity, or the physical closeness of molecules, is a pervasive regulatory mechanism in biology. For example, most posttranslational modifications such as phosphorylation, methylation, and acetylation promote proximity of molecules to play deterministic roles in cellular processes. To understand the role of proximity in biologic mechanisms, chemical inducers of proximity (CIPs) were developed to synthetically model biologically regulated recruitment. Chemically induced proximity allows for precise temporal control of transcription, signaling cascades, chromatin regulation, protein folding, localization, and degradation, as well as a host of other biologic processes. A systematic analysis of CIPs in basic research, coupled with recent technological advances utilizing CRISPR, distinguishes roles of causality from coincidence and allows for mathematical modeling in synthetic biology. Recently, induced proximity has provided new avenues of gene therapy and emerging advances in cancer treatment. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000435220500001 |
WOS关键词 | E3 UBIQUITIN LIGASE ; BET BROMODOMAIN INHIBITION ; ARTIFICIAL DEATH SWITCHES ; SMALL-MOLECULE PROTACS ; STEM-CELL TRANSPLANT ; IN-VIVO ; T-CELLS ; LIVING CELLS ; ENDOPLASMIC-RETICULUM ; INDUCED DIMERIZATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198146 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA; 2.Stanford Univ, Sch Med, Dept Dev Biol, Stanford, CA 94305 USA; 3.Natl Ctr Adv Translat Sci, Div Preclin Innovat, NIH, Rockville, MD 20850 USA; 4.Stanford Univ, Dept Chem Engn, Stanford, CA 94305 USA; 5.Stanford Univ, Howard Hughes Med Inst, Sch Med, Stanford, CA 94305 USA |
推荐引用方式 GB/T 7714 | Stanton, Benjamin Z.,Chory, Emma J.,Crabtree, Gerald R.. Chemically induced proximity in biology and medicine[J]. SCIENCE,2018,359(6380). |
APA | Stanton, Benjamin Z.,Chory, Emma J.,&Crabtree, Gerald R..(2018).Chemically induced proximity in biology and medicine.SCIENCE,359(6380). |
MLA | Stanton, Benjamin Z.,et al."Chemically induced proximity in biology and medicine".SCIENCE 359.6380(2018). |
条目包含的文件 | 条目无相关文件。 |
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