Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aar7201 |
Translocation of a gut pathobiont drives autoimmunity in mice and humans | |
Vieira, S. Manfredo1; Hiltensperger, M.1; Kumar, V.2; Zegarra-Ruiz, D.1; Dehner, C.1; Khan, N.1; Costa, F. R. C.1,7; Tiniakou, E.1,8; Greiling, T.1,9; Ruff, W.1; Barbieri, A.3; Kriegel, C.1; Mehta, S. S.4; Knight, J. R.4; Jain, D.3; Goodman, A. L.5,6; Kriegel, M. A.1,2 | |
2018-03-09 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 359期号:6380页码:1156-1160 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Brazil |
英文摘要 | Despite multiple associations between the microbiota and immune diseases, their role in autoimmunity is poorly understood. We found that translocation of a gut pathobiont, Enterococcus gallinarum, to the liver and other systemic tissues triggers autoimmune responses in a genetic background predisposing to autoimmunity. Antibiotic treatment prevented mortality in this model, suppressed growth of E. gallinarum in tissues, and eliminated pathogenic autoantibodies and T cells. Hepatocyte-E. gallinarum cocultures induced autoimmune-promoting factors. Pathobiont translocation in monocolonized and autoimmuneprone mice induced autoantibodies and caused mortality, which could be prevented by an intramuscular vaccine targeting the pathobiont. E. gallinarum-specific DNA was recovered from liver biopsies of autoimmune patients, and cocultures with human hepatocytes replicated the murine findings; hence, similar processes apparently occur in susceptible humans. These discoveries show that a gut pathobiont can translocate and promote autoimmunity in genetically predisposed hosts. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000426835900046 |
WOS关键词 | RESIDENT COMMENSAL BACTERIA ; ENDOGENOUS RETROVIRUSES ; MICROBIOTA ; INFECTION ; IMMUNITY ; CELLS ; INNATE ; DISSEMINATION ; PATHOGENESIS ; ACTIVATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198140 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Yale Sch Med, Dept Immunobiol, New Haven, CT 06510 USA; 2.Yale Sch Med, Dept Med, New Haven, CT 06510 USA; 3.Yale Sch Med, Dept Pathol, New Haven, CT USA; 4.Yale Sch Med, Yale Ctr Genome Anal, New Haven, CT USA; 5.Yale Sch Med, Dept Microbial Pathogenesis, New Haven, CT USA; 6.Yale Sch Med, Microbial Sci Inst, New Haven, CT USA; 7.Ribeirao Preto Med Sch, Dept Biochem & Immunol, Ribeirao Preto, SP, Brazil; 8.Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA; 9.Oregon Hlth & Sci Univ, Dept Dermatol, Portland, OR 97201 USA |
推荐引用方式 GB/T 7714 | Vieira, S. Manfredo,Hiltensperger, M.,Kumar, V.,et al. Translocation of a gut pathobiont drives autoimmunity in mice and humans[J]. SCIENCE,2018,359(6380):1156-1160. |
APA | Vieira, S. Manfredo.,Hiltensperger, M..,Kumar, V..,Zegarra-Ruiz, D..,Dehner, C..,...&Kriegel, M. A..(2018).Translocation of a gut pathobiont drives autoimmunity in mice and humans.SCIENCE,359(6380),1156-1160. |
MLA | Vieira, S. Manfredo,et al."Translocation of a gut pathobiont drives autoimmunity in mice and humans".SCIENCE 359.6380(2018):1156-1160. |
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