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DOI | 10.1126/science.aao2140 |
Incomplete host immunity favors the evolution of virulence in an emergent pathogen | |
Fleming-Davies, Arietta E.1,2,3; Williams, Paul D.4; Dhondt, Andre A.5; Dobson, Andrew P.4,6; Hochachka, Wesley M.5; Leon, Ariel E.2; Ley, David H.7; Osnas, Erik E.8; Hawley, Dana M.2 | |
2018-03-02 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 359期号:6379页码:1030-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Immune memory evolved to protect hosts from reinfection, but incomplete responses that allow future reinfection may inadvertently select for more-harmful pathogens. We present empirical and modeling evidence that incomplete immunity promotes the evolution of higher virulence in a natural host-pathogen system. We performed sequential infections of house finches with Mycoplasma gallisepticum strains of various levels of virulence. Virulent bacterial strains generated stronger host protection against reinfection than less virulent strains and thus excluded less virulent strains from infecting previously exposed hosts. In a two-strain model, the resulting fitness advantage selected for an almost twofold increase in pathogen virulence. Thus, the same immune systems that protect hosts from infection can concomitantly drive the evolution of more-harmful pathogens in nature. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000426366200041 |
WOS关键词 | MYCOPLASMA-GALLISEPTICUM INFECTION ; IN-HOUSE FINCHES ; RESISTANCE ; REINFECTION ; DYNAMICS ; DISEASE ; VIRUS ; TRANSMISSION ; VACCINATION ; POPULATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198095 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ San Diego, Dept Biol, San Diego, CA 92110 USA; 2.Virginia Tech, Dept Biol Sci, Blacksburg, VA 24061 USA; 3.Radford Univ, Dept Biol, Radford, VA 24141 USA; 4.Princeton Univ, Dept Ecol & Evolutionary Biol, Princeton, NJ 08544 USA; 5.Cornell Univ, Lab Ornithol, Ithaca, NY 14850 USA; 6.Santa Fe Inst, Santa Fe, NM 87501 USA; 7.North Carolina State Univ, Dept Populat Hlth & Pathobiol, Coll Vet Med, Raleigh, NC 27607 USA; 8.US Fish & Wildlife Serv, Anchorage, AK 99503 USA |
推荐引用方式 GB/T 7714 | Fleming-Davies, Arietta E.,Williams, Paul D.,Dhondt, Andre A.,et al. Incomplete host immunity favors the evolution of virulence in an emergent pathogen[J]. SCIENCE,2018,359(6379):1030-+. |
APA | Fleming-Davies, Arietta E..,Williams, Paul D..,Dhondt, Andre A..,Dobson, Andrew P..,Hochachka, Wesley M..,...&Hawley, Dana M..(2018).Incomplete host immunity favors the evolution of virulence in an emergent pathogen.SCIENCE,359(6379),1030-+. |
MLA | Fleming-Davies, Arietta E.,et al."Incomplete host immunity favors the evolution of virulence in an emergent pathogen".SCIENCE 359.6379(2018):1030-+. |
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