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DOI | 10.1126/science.aao3264 |
An evolutionarily conserved gene family encodes proton-selective ion channels | |
Tu, Yu-Hsiang1; Cooper, Alexander J.1,4; Teng, Bochuan1; Chang, Rui B.1,5,6; Artiga, Daniel J.1; Turner, Heather N.1; Mulhall, Eric M.1,7; Ye, Wenlei1,8; Smith, Andrew D.2; Liman, Emily R.1,3 | |
2018-03-02 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 359期号:6379页码:1047-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Ion channels form the basis for cellular electrical signaling. Despite the scores of genetically identified ion channels selective for other monatomic ions, only one type of proton-selective ion channel has been found in eukaryotic cells. By comparative transcriptome analysis of mouse taste receptor cells, we identified Otopetrin1 (OTOP1), a protein required for development of gravity-sensing otoconia in the vestibular system, as forming a proton-selective ion channel. We found that murine OTOP1 is enriched in acid-detecting taste receptor cells and is required for their zinc-sensitive proton conductance. Two related murine genes, Otop2 and Otop3, and a Drosophila ortholog also encode proton channels. Evolutionary conservation of the gene family and its widespread tissue distribution suggest a broad role for proton channels in physiology and pathophysiology. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000426366200045 |
WOS关键词 | CELLS ; TASTE ; PROTEIN ; DOMAIN ; MICE ; PH |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198093 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Southern Calif, Sect Neurobiol, Dept Biol Sci, Los Angeles, CA 90089 USA; 2.Univ Southern Calif, Dept Biol Sci, Sect Mol & Computat Biol, Los Angeles, CA 90089 USA; 3.Univ Southern Calif, Bridge Inst, Los Angeles, CA 90089 USA; 4.Univ Southern Calif, Keck Sch Med, Dept Cell & Neurobiol, Zilkha Neurogenet Inst, Los Angeles, CA 90089 USA; 5.Yale Univ, Sch Med, Dept Neurosci, New Haven, CT 06520 USA; 6.Yale Univ, Sch Med, Dept Cellular & Mol Physiol, New Haven, CT 06520 USA; 7.Harvard Med Sch, Dept Neurobiol, Boston, MA 20115 USA; 8.Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94158 USA |
推荐引用方式 GB/T 7714 | Tu, Yu-Hsiang,Cooper, Alexander J.,Teng, Bochuan,et al. An evolutionarily conserved gene family encodes proton-selective ion channels[J]. SCIENCE,2018,359(6379):1047-+. |
APA | Tu, Yu-Hsiang.,Cooper, Alexander J..,Teng, Bochuan.,Chang, Rui B..,Artiga, Daniel J..,...&Liman, Emily R..(2018).An evolutionarily conserved gene family encodes proton-selective ion channels.SCIENCE,359(6379),1047-+. |
MLA | Tu, Yu-Hsiang,et al."An evolutionarily conserved gene family encodes proton-selective ion channels".SCIENCE 359.6379(2018):1047-+. |
条目包含的文件 | 条目无相关文件。 |
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