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DOI | 10.1126/science.aad6469 |
Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap | |
Gandal, Michael J.1,2,3,4; Haney, Jillian R.1,2,3; Parikshak, Neelroop N.1,2,3; Leppa, Virpi1,2,3; Ramaswami, Gokul1,2,3; Hartl, Chris1,2,3; Schork, Andrew J.5; Appadurai, Vivek5; Buil, Alfonso5; Werge, Thomas M.5,6,7; Liu, Chunyu8,9; White, Kevin P.10,11; Horvath, Steve3; Geschwind, Daniel H.1,2,3 | |
2018-02-09 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 359期号:6376页码:693-697 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Denmark; Peoples R China |
英文摘要 | The predisposition to neuropsychiatric disease involves a complex, polygenic, and pleiotropic genetic architecture. However, little is known about how genetic variants impart brain dysfunction or pathology. We used transcriptomic profiling as a quantitative readout of molecular brain-based phenotypes across five major psychiatric disorders-autism, schizophrenia, bipolar disorder, depression, and alcoholism-compared with matched controls. We identified patterns of shared and distinct gene-expression perturbations across these conditions. The degree of sharing of transcriptional dysregulation is related to polygenic (single-nucleotide polymorphism-based) overlap across disorders, suggesting a substantial causal genetic component. This comprehensive systems-level view of the neurobiological architecture of major neuropsychiatric illness demonstrates pathways of molecular convergence and specificity. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E ; SSCI |
WOS记录号 | WOS:000425117700042 |
WOS关键词 | GENOME-WIDE ASSOCIATION ; DE-NOVO MUTATIONS ; GENE-EXPRESSION ; COEXPRESSION NETWORKS ; BIPOLAR DISORDER ; HIGH-RISK ; AUTISM ; SCHIZOPHRENIA ; BRAIN ; MICRODELETIONS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197954 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Calif Los Angeles, David Geffen Sch Med, Semel Inst, Program Neurobehav Genet, Los Angeles, CA 90095 USA; 2.Univ Calif Los Angeles, David Geffen Sch Med, Semel Inst, Ctr Autism Res & Treatment,Dept Neurol, 695 Charles E Young Dr South, Los Angeles, CA 90095 USA; 3.Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA; 4.Univ Calif Los Angeles, David Geffen Sch Med, Semel Inst, Dept Psychiat, 695 Charles E Young Dr South, Los Angeles, CA 90095 USA; 5.Mental Hlth Serv Copenhagen, Inst Biol Psychiat, Copenhagen, Denmark; 6.iPSYCH, Lundbeck Fdn Initiat Integrat Psychiat Res, Copenhagen, Denmark; 7.Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark; 8.Univ Illinois, Dept Psychiat, Chicago, IL 60612 USA; 9.Cent S Univ, State Key Lab Med Genet, Changsha, Hunan, Peoples R China; 10.Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA; 11.Tempus Labs, 600 W Chicago Ave, Chicago, IL 60654 USA |
推荐引用方式 GB/T 7714 | Gandal, Michael J.,Haney, Jillian R.,Parikshak, Neelroop N.,et al. Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap[J]. SCIENCE,2018,359(6376):693-697. |
APA | Gandal, Michael J..,Haney, Jillian R..,Parikshak, Neelroop N..,Leppa, Virpi.,Ramaswami, Gokul.,...&Geschwind, Daniel H..(2018).Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap.SCIENCE,359(6376),693-697. |
MLA | Gandal, Michael J.,et al."Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap".SCIENCE 359.6376(2018):693-697. |
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