Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aah3648 |
Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria | |
Dejea, Christine M.1,2,9; Fathi, Payam1,2,3,10; Craig, John M.4; Boleij, Annemarie1,5; Taddese, Rahwa5; Geis, Abby L.1,2,11; Wu, Xinqun1,3; Shields, Christina E. DeStefano1,2; Hechenbleikner, Elizabeth M.6,12; Huso, David L.7; Anders, Robert A.8; Giardiello, Francis M.2,3; Wick, Elizabeth C.6,13; Wang, Hao1,2; Wu, Shaoguang1,3; Pardoll, Drew M.1,2; Housseau, Franck1,2; Sears, Cynthia L.1,2,3 | |
2018-02-02 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 359期号:6375页码:592-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Netherlands |
英文摘要 | Individuals with sporadic colorectal cancer (CRC) frequently harbor abnormalities in the composition of the gut microbiome; however, the microbiota associated with precancerous lesions in hereditary CRC remains largely unknown. We studied colonic mucosa of patients with familial adenomatous polyposis (FAP), who develop benign precursor lesions (polyps) early in life. We identified patchy bacterial biofilms composed predominately of Escherichia coli and Bacteroides fragilis. Genes for colibactin (clbB) and Bacteroides fragilis toxin (bft), encoding secreted oncotoxins, were highly enriched in FAP patients' colonic mucosa compared to healthy individuals. Tumor-prone mice cocolonized with E. coli (expressing colibactin), and enterotoxigenic B. fragilis showed increased interleukin-17 in the colon and DNA damage in colonic epithelium with faster tumor onset and greater mortality, compared to mice with either bacterial strain alone. These data suggest an unexpected link between early neoplasia of the colon and tumorigenic bacteria. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000423795800046 |
WOS关键词 | INFLAMMATORY-BOWEL-DISEASE ; CANCER ; GENE ; MICROBIOTA ; MUCOSA |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197907 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Johns Hopkins Univ, Bloomberg Kimmel Inst Canc Immunotherapy, Baltimore, MD 21218 USA; 2.Johns Hopkins Univ, Dept Oncol, Baltimore, MD 21218 USA; 3.Johns Hopkins Univ, Dept Med, Baltimore, MD 21218 USA; 4.Johns Hopkins Univ, Dept Environm Hlth Sci, Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA; 5.Radboud Univ Nijmegen, Dept Pathol, Med Ctr, Postbus 9101, NL-6500 HB Nijmegen, Netherlands; 6.Johns Hopkins Univ, Dept Surg, Baltimore, MD USA; 7.Johns Hopkins Univ, Dept Mol & Comparat Pathobiol, Baltimore, MD USA; 8.Johns Hopkins Univ, Dept Pathol, Baltimore, MD USA; 9.10903 New Hampshire Ave,WO22 RM 5171, Silver Spring, MD 20993 USA; 10.Vanderbilt Univ, Sch Med, 340 Light Hall, Nashville, TN 37232 USA; 11.Arkansas Coll Osteopath Med, 7000 Chad Colley Blvd, Ft Smith, AR 72916 USA; 12.Mt Sinai Hosp, Dept Surg, 5 East 98th St, New York, NY 10029 USA; 13.Univ Calif San Francisco, Dept Surg, 513 Parnassus Ave,S 549, San Francisco, CA 94143 USA |
推荐引用方式 GB/T 7714 | Dejea, Christine M.,Fathi, Payam,Craig, John M.,et al. Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria[J]. SCIENCE,2018,359(6375):592-+. |
APA | Dejea, Christine M..,Fathi, Payam.,Craig, John M..,Boleij, Annemarie.,Taddese, Rahwa.,...&Sears, Cynthia L..(2018).Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria.SCIENCE,359(6375),592-+. |
MLA | Dejea, Christine M.,et al."Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria".SCIENCE 359.6375(2018):592-+. |
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