A primordial and reversible TCA cycle in a facultatively chemolithoautotrophic thermophile

doi:10.1126/science.aao3407

GSTDTAP > 地球科学

DOI	10.1126/science.aao3407
	A primordial and reversible TCA cycle in a facultatively chemolithoautotrophic thermophile
	Nunoura, Takuro 1; Chikaraishi, Yoshito 1,2,3; Izaki, Rikihisa 4; Suwa, Takashi 4; Sato, Takaaki 4; Harada, Takeshi 5; Mori, Koji 5; Kato, Yumiko 5; Miyazaki, Masayuki 1,6; Shimamura, Shigeru 6; Yanagawa, Katsunori 6,8; Shuto, Aya 1; Ohkouchi, Naohiko 2; Fujita, Nobuyuki 5,9; Takaki, Yoshihiro 1,6; Atomi, Haruyuki 4,7; Takai, Ken 6
	2018-02-02
发表期刊	SCIENCE
ISSN	0036-8075
EISSN	1095-9203
出版年	2018
卷号	359 期号:6375 页码:559-562
文章类型	Article
语种	英语
国家	Japan
英文摘要	Inorganic carbon fixation is essential to sustain life on Earth, and the reductive tricarboxylic acid (rTCA) cycle is one of the most ancient carbon fixation metabolisms. A combination of genomic, enzymatic, and metabolomic analyses of a deeply branching chemolithotrophic Thermosulfidibacter takaii ABI70S6(T) revealed a previously unknown reversible TCA cycle whose direction was controlled by the available carbon source(s). Under a chemolithoautotrophic condition, a rTCA cycle occurred with the reverse reaction of citrate synthase (CS) and not with the adenosine 5'-triphosphate-dependent citrate cleavage reactions that had been regarded as essential for the conventional rTCA cycle. Phylometabolic evaluation suggests that the TCA cycle with reversible CS may represent an ancestral mode of the rTCA cycle and raises the possibility of a facultatively chemolithomixotrophic origin of life.
领域	地球科学 ; 气候变化 ; 资源环境
收录类别	SCI-E
WOS记录号	WOS:000423795800038
WOS关键词	ATP-CITRATE LYASE ; AUTOTROPHIC CARBON FIXATION ; PURIFICATION ; EVOLUTION ; SYNTHASE ; ENZYME ; ACID
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
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引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/197899
专题	地球科学资源环境科学气候变化
作者单位	1.Japan Agcy Marine Earth Sci & Technol JAMSTEC, Res & Dev Ctr Marine Biosci, 2-15 Natsushima Cho, Yokosuka, Kanagawa 2370061, Japan; 2.Japan Agcy Marine Earth Sci & Technol JAMSTEC, Dept Biogeochem, 2-15 Natsushima Cho, Yokosuka, Kanagawa 2370061, Japan; 3.Hokkaido Univ, Inst Low Temp Sci, Kita Ku, Kita 19,Nishi 8, Sapporo, Hokkaido 0600819, Japan; 4.Kyoto Univ, Grad Sch Engn, Dept Synthet Chem & Biol Chem, Nishikyo Ku, Kyoto 6158510, Japan; 5.NITE, NBRC, Shibuya Ku, 2-49-10 Nishihara, Tokyo 1510066, Japan; 6.Japan Agcy Marine Earth Sci & Technol JAMSTEC, Dept Subsurface Geobiol Anal & Res, 2-15 Natsushima Cho, Yokosuka, Kanagawa 2370061, Japan; 7.Japan Sci & Technol Agcy JST, CREST, Chiyoda Ku, 7 Goban Cho, Tokyo 1020076, Japan; 8.Univ Kitakyushu, Fac Environm Engn, Kitakyushu, Fukuoka, Japan; 9.Tokyo Univ Agr, Fac Life Sci, Tokyo, Japan
推荐引用方式 GB/T 7714	Nunoura, Takuro,Chikaraishi, Yoshito,Izaki, Rikihisa,et al. A primordial and reversible TCA cycle in a facultatively chemolithoautotrophic thermophile[J]. SCIENCE,2018,359(6375):559-562.
APA	Nunoura, Takuro.,Chikaraishi, Yoshito.,Izaki, Rikihisa.,Suwa, Takashi.,Sato, Takaaki.,...&Takai, Ken.(2018).A primordial and reversible TCA cycle in a facultatively chemolithoautotrophic thermophile.SCIENCE,359(6375),559-562.
MLA	Nunoura, Takuro,et al."A primordial and reversible TCA cycle in a facultatively chemolithoautotrophic thermophile".SCIENCE 359.6375(2018):559-562.