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DOI | 10.1126/science.aah6834 |
Membrane protein insertion through a mitochondrial beta-barrel gate | |
Hohr, Alexandra I. C.1,2; Lindau, Caroline1,2; Wirth, Christophe1; Qiu, Jian1,5; Stroud, David A.1,6,7; Kutik, Stephan1; Guiard, Bernard3; Hunte, Carola1,4; Becker, Thomas1,4; Pfanner, Nikolaus1,4; Wiedemann, Nils1,4 | |
2018-01-19 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 359期号:6373页码:289-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Germany; France; Switzerland; Australia |
英文摘要 | The biogenesis of mitochondria, chloroplasts, and Gram-negative bacteria requires the insertion of beta-barrel proteins into the outer membranes. Homologous Omp85 proteins are essential for membrane insertion of beta-barrel precursors. It is unknown if precursors are threaded through the Omp85-channel interior and exit laterally or if they are translocated into the membrane at the Omp85-lipid interface. We have mapped the interaction of a precursor in transit with the mitochondrial Omp85-channel Sam50 in the native membrane environment. The precursor is translocated into the channel interior, interacts with an internal loop, and inserts into the lateral gate by beta-signal exchange. Transport through the Omp85-channel interior followed by release through the lateral gate into the lipid phase may represent a basic mechanism for membrane insertion of beta-barrel proteins. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000423236700030 |
WOS关键词 | OUTER-MEMBRANE ; ASSEMBLY MACHINERY ; STRUCTURAL BASIS ; PERIPLASMIC CHAPERONES ; ESSENTIAL COMPONENT ; CRYSTAL-STRUCTURE ; BIOGENESIS ; BAMA ; COMPLEX ; TRANSLOCATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197813 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Freiburg, Inst Biochem & Mol Biol, Fac Med, Ctr Biochem & Mol Cell Res ZBMZ, D-79104 Freiburg, Germany; 2.Univ Freiburg, Fac Biol, D-79104 Freiburg, Germany; 3.CNRS, Ctr Genet Mol, F-91190 Gif Sur Yvette, France; 4.Univ Freiburg, BIOSS Ctr Biol Signalling Studies, D-79104 Freiburg, Germany; 5.Swiss Fed Inst Technol EPFL, CH-1015 Lausanne, Switzerland; 6.Univ Melbourne, Dept Biochem & Mol Biol, Parkville, Vic 3010, Australia; 7.Univ Melbourne, Mol Sci & Biotechnol Inst Bio21, Parkville, Vic 3010, Australia |
推荐引用方式 GB/T 7714 | Hohr, Alexandra I. C.,Lindau, Caroline,Wirth, Christophe,et al. Membrane protein insertion through a mitochondrial beta-barrel gate[J]. SCIENCE,2018,359(6373):289-+. |
APA | Hohr, Alexandra I. C..,Lindau, Caroline.,Wirth, Christophe.,Qiu, Jian.,Stroud, David A..,...&Wiedemann, Nils.(2018).Membrane protein insertion through a mitochondrial beta-barrel gate.SCIENCE,359(6373),289-+. |
MLA | Hohr, Alexandra I. C.,et al."Membrane protein insertion through a mitochondrial beta-barrel gate".SCIENCE 359.6373(2018):289-+. |
条目包含的文件 | 条目无相关文件。 |
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