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DOI | 10.1126/science.aah6499 |
The epigenetic control of stemness in CD8(+) T cell fate commitment | |
Pace, Luigia1,2,3,8; Goudot, Christel1,2; Zueva, Elina1,2; Gueguen, Paul1,2; Burgdorf, Nina1,2; Waterfall, Joshua J.1,4,5; Quivy, Jean-Pierre1,6,7; Almouzni, Genevieve1,6,7; Amigorena, Sebastian1,2 | |
2018-01-12 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 359期号:6372页码:177-+ |
文章类型 | Article |
语种 | 英语 |
国家 | France; Italy |
英文摘要 | After priming, naive CD8(+) T lymphocytes establish specific heritable transcription programs that define progression to long-lasting memory cells or to short-lived effector cells. Although lineage specification is critical for protection, it remains unclear how chromatin dynamics contributes to the control of gene expression programs. We explored the role of gene silencing by the histone methyltransferase Suv39h1. In murine CD8(+) T cells activated after Listeria monocytogenes infection, Suv39h1-dependent trimethylation of histone H3 lysine 9 controls the expression of a set of stem cell-related memory genes. Single-cell RNA sequencing revealed a defect in silencing of stem/memory genes selectively in Suv39h1-defective T cell effectors. As a result, Suv39h1-defective CD8(+) T cells show sustained survival and increased long-term memory reprogramming capacity. Thus, Suv39h1 plays a critical role in marking chromatin to silence stem/memory genes during CD8(+) T effector terminal differentiation. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000419816600039 |
WOS关键词 | HETEROCHROMATIN MAINTENANCE ; MEMORY ; EFFECTOR ; DIFFERENTIATION ; EXPRESSION ; GENES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197759 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.PSL Res Univ, Inst Curie, F-75005 Paris, France; 2.INSERM U932, Equipes Labellisees Ligue Canc, F-75005 Paris, France; 3.Italian Inst Genom Med, Armenise Harvard Lab, Turin, Italy; 4.INSERM U830, F-75005 Paris, France; 5.Inst Curie, Translat Res Dept, F-75005 Paris, France; 6.CNRS, Equipe Labellisee Ligue Canc, UMR3664, F-75005 Paris, France; 7.UPMC Univ Paris 06, Sorbonne Univ, CNRS, UMR3664, F-75005 Paris, France; 8.Italian Inst Genom Med, Turin, Italy |
推荐引用方式 GB/T 7714 | Pace, Luigia,Goudot, Christel,Zueva, Elina,et al. The epigenetic control of stemness in CD8(+) T cell fate commitment[J]. SCIENCE,2018,359(6372):177-+. |
APA | Pace, Luigia.,Goudot, Christel.,Zueva, Elina.,Gueguen, Paul.,Burgdorf, Nina.,...&Amigorena, Sebastian.(2018).The epigenetic control of stemness in CD8(+) T cell fate commitment.SCIENCE,359(6372),177-+. |
MLA | Pace, Luigia,et al."The epigenetic control of stemness in CD8(+) T cell fate commitment".SCIENCE 359.6372(2018):177-+. |
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