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DOI | 10.1126/science.aan4325 |
Structure of the cold- and menthol-sensing ion channel TRPM8 | |
Yin, Ying1; Wu, Mengyu2; Zubcevic, Lejla1; Borschel, William F.1; Lander, Gabriel C.2; Lee, Seok-Yong1 | |
2018-01-12 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 359期号:6372页码:237-241 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Transient receptor potential melastatin (TRPM) cation channels are polymodal sensors that are involved in a variety of physiological processes. Within the TRPM family, member 8 (TRPM8) is the primary cold and menthol sensor in humans. We determined the cryo-electron microscopy structure of the full-length TRPM8 from the collared flycatcher at an overall resolution of similar to 4.1 angstroms. Our TRPM8 structure reveals a three-layered architecture. The amino-terminal domain with a fold distinct among known TRP structures, together with the carboxyl-terminal region, forms a large two-layered cytosolic ring that extensively interacts with the transmembrane channel layer. The structure suggests that the menthol-binding site is located within the voltage-sensor-like domain and thus provides a structural glimpse of the design principle of the molecular transducer for cold and menthol sensation. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000419816600051 |
WOS关键词 | CRYOELECTRON MICROSCOPY STRUCTURE ; TRPV1 STRUCTURES ; K+ CHANNEL ; REVEALS ; ACTIVATION ; DOMAIN ; PAIN ; MECHANISMS ; FEATURES ; STIMULI |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197757 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Duke Univ, Sch Med, Dept Biochem, Durham, NC 27710 USA; 2.Scripps Res Inst, Dept Integrat Struct & Computat Biol, La Jolla, CA 92037 USA |
推荐引用方式 GB/T 7714 | Yin, Ying,Wu, Mengyu,Zubcevic, Lejla,et al. Structure of the cold- and menthol-sensing ion channel TRPM8[J]. SCIENCE,2018,359(6372):237-241. |
APA | Yin, Ying,Wu, Mengyu,Zubcevic, Lejla,Borschel, William F.,Lander, Gabriel C.,&Lee, Seok-Yong.(2018).Structure of the cold- and menthol-sensing ion channel TRPM8.SCIENCE,359(6372),237-241. |
MLA | Yin, Ying,et al."Structure of the cold- and menthol-sensing ion channel TRPM8".SCIENCE 359.6372(2018):237-241. |
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