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DOI | 10.1126/science.aao1503 |
CX3CR1(+) mononuclear phagocytes control immunity to intestinal fungi | |
Leonardi, Irina1,2; Li, Xin1,2; Semon, Alexa1,2; Li, Dalin3; Doron, Itai1,2; Putzel, Gregory2; Bar, Agnieszka1,2; Prieto, Daniel4; Rescigno, Maria5; McGovern, Dermot P. B.3; Pla, Jesus4; Iliev, Iliyan D.1,2,6 | |
2018-01-12 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 359期号:6372页码:232-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Spain; Italy |
英文摘要 | Intestinal fungi are an important component of the microbiota, and recent studies have unveiled their potential in modulating host immune homeostasis and inflammatory disease. Nonetheless, the mechanisms governing immunity to gut fungal communities (mycobiota) remain unknown. We identified CX3CR1(+) mononuclear phagocytes (MNPs) as being essential for the initiation of innate and adaptive immune responses to intestinal fungi. CX3CR1(+) MNPs express antifungal receptors and activate antifungal responses in a Syk-dependent manner. Genetic ablation of CX3CR1(+) MNPs in mice led to changes in gut fungal communities and to severe colitis that was rescued by antifungal treatment. In Crohn's disease patients, a missense mutation in the gene encoding CX3CR1 was identified and found to be associated with impaired antifungal responses. These results unravel a role of CX3CR1(+) MNPs in mediating interactions between intestinal mycobiota and host immunity at steady state and during inflammatory disease. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000419816600050 |
WOS关键词 | CD103(+)CD11B(+) DENDRITIC CELLS ; SACCHAROMYCES-CEREVISIAE ; CANDIDA-ALBICANS ; RECEPTOR CX3CR1 ; CROHNS-DISEASE ; TH17 RESPONSES ; POLYMORPHISM ; MICE ; ASSOCIATION ; MACROPHAGES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197754 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Weill Cornell Med, Gastroenterol & Hepatol Div, Joan & Sanford I Weill Dept Med, New York, NY 10021 USA; 2.Weill Cornell Med, Jill Roberts Inst Res Inflammatory Bowel Dis, New York, NY 10021 USA; 3.Cedars Sinai Med Ctr, F Widjaja Inflammatory Bowel & Immunobiol Res Ins, Los Angeles, CA 90048 USA; 4.Univ Complutense Madrid, Fac Farm, Dept Microbiol 2, E-28040 Madrid, Spain; 5.European Inst Oncol, Dept Expt Oncol, I-20141 Milan, Italy; 6.Weill Cornell Med, Dept Microbiol & Immunol, New York, NY 10065 USA |
推荐引用方式 GB/T 7714 | Leonardi, Irina,Li, Xin,Semon, Alexa,et al. CX3CR1(+) mononuclear phagocytes control immunity to intestinal fungi[J]. SCIENCE,2018,359(6372):232-+. |
APA | Leonardi, Irina.,Li, Xin.,Semon, Alexa.,Li, Dalin.,Doron, Itai.,...&Iliev, Iliyan D..(2018).CX3CR1(+) mononuclear phagocytes control immunity to intestinal fungi.SCIENCE,359(6372),232-+. |
MLA | Leonardi, Irina,et al."CX3CR1(+) mononuclear phagocytes control immunity to intestinal fungi".SCIENCE 359.6372(2018):232-+. |
条目包含的文件 | 条目无相关文件。 |
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