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DOI | 10.1126/science.aap8775 |
Antagonism toward the intestinal microbiota and its effect on Vibrio cholerae virulence | |
Zhao, Wenjing; Caro, Florence; Robins, William; Mekalanos, John J. | |
2018-01-12 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 359期号:6372页码:210-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | The bacterial type VI secretion system (T6SS) is a nanomachine that delivers toxic effector proteins into target cells, killing them. In mice, we found that the Vibrio cholerae T6SS attacks members of the host commensal microbiota in vivo, facilitating the pathogen's colonization of the gut. This microbial antagonistic interaction drives measurable changes in the pathogenicity of V. cholerae through enhanced intestinal colonization, expression of bacterial virulence genes, and activation of host innate immune genes. Because ablation of mouse commensals by this enteric pathogen correlated with more severe diarrheal symptoms, we conclude that antagonism toward the gut microbiota could improve the fitness of V. cholerae as a pathogen by elevating its transmission to new susceptible hosts. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000419816600045 |
WOS关键词 | VI SECRETION SYSTEM ; HOST ; INFECTION ; MODEL ; GUT |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197745 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | Harvard Med Sch, Dept Microbiol & Immunobiol, Boston, MA 02115 USA |
推荐引用方式 GB/T 7714 | Zhao, Wenjing,Caro, Florence,Robins, William,et al. Antagonism toward the intestinal microbiota and its effect on Vibrio cholerae virulence[J]. SCIENCE,2018,359(6372):210-+. |
APA | Zhao, Wenjing,Caro, Florence,Robins, William,&Mekalanos, John J..(2018).Antagonism toward the intestinal microbiota and its effect on Vibrio cholerae virulence.SCIENCE,359(6372),210-+. |
MLA | Zhao, Wenjing,et al."Antagonism toward the intestinal microbiota and its effect on Vibrio cholerae virulence".SCIENCE 359.6372(2018):210-+. |
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