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DOI | 10.1126/science.aar4510 |
Structure of the human TRPM4 ion channel in a lipid nanodisc | |
Autzen, Henriette E.1,2; Myasnikov, Alexander G.1; Campbell, Melody G.1; Asarnow, Daniel1; Julius, David3; Cheng, Yifan1,4 | |
2018-01-12 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 359期号:6372页码:228-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Denmark |
英文摘要 | Transient receptor potential (TRP) melastatin 4 (TRPM4) is a widely expressed cation channel associated with a variety of cardiovascular disorders. TRPM4 is activated by increased intracellular calcium in a voltage-dependent manner but, unlike many other TRP channels, is permeable to monovalent cations only. Here we present two structures of full-length human TRPM4 embedded in lipid nanodiscs at similar to 3-angstrom resolution, as determined by single-particle cryo-electron microscopy. These structures, with and without calcium bound, reveal a general architecture for this major subfamily of TRP channels and a well-defined calcium-binding site within the intracellular side of the S1-S4 domain. The structures correspond to two distinct closed states. Calcium binding induces conformational changes that likely prime the channel for voltage-dependent opening. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000419816600049 |
WOS关键词 | TRPV1 STRUCTURES ; N-TERMINUS ; CATION ; REVEALS ; DOMAIN |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197740 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA; 2.Univ Aarhus, Dept Mol Biol & Genet, DK-8000 Aarhus, Denmark; 3.Univ Calif San Francisco, Dept Physiol, Box 0444, San Francisco, CA 94143 USA; 4.Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA |
推荐引用方式 GB/T 7714 | Autzen, Henriette E.,Myasnikov, Alexander G.,Campbell, Melody G.,et al. Structure of the human TRPM4 ion channel in a lipid nanodisc[J]. SCIENCE,2018,359(6372):228-+. |
APA | Autzen, Henriette E.,Myasnikov, Alexander G.,Campbell, Melody G.,Asarnow, Daniel,Julius, David,&Cheng, Yifan.(2018).Structure of the human TRPM4 ion channel in a lipid nanodisc.SCIENCE,359(6372),228-+. |
MLA | Autzen, Henriette E.,et al."Structure of the human TRPM4 ion channel in a lipid nanodisc".SCIENCE 359.6372(2018):228-+. |
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