GSTDTAP  > 地球科学
DOI10.1126/science.aam8825
Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells
Ramsuran, Veron1; 39;u, Thumbi2
2018-01-05
发表期刊SCIENCE
ISSN0036-8075
EISSN1095-9203
出版年2018
卷号359期号:6371页码:86-90
文章类型Article
语种英语
国家USA; South Africa; England; Switzerland; Germany
英文摘要

The highly polymorphic human leukocyte antigen (HLA) locus encodes cell surface proteins that are critical for immunity. HLA-A expression levels vary in an allele-dependent manner, diversifying allele-specific effects beyond peptide-binding preference. Analysis of 9763 HIV-infected individuals from 21 cohorts shows that higher HLA-A levels confer poorer control of HIV. Elevated HLA-A expression provides enhanced levels of an HLA-A-derived signal peptide that specifically binds and determines expression levels of HLA-E, the ligand for the inhibitory NKG2A natural killer (NK) cell receptor. HLA-B haplotypes that favor NKG2A-mediated NK cell licensing (i.e., education) exacerbate the deleterious effect of high HLA-A on HIV control, consistent with NKG2A-mediated inhibition impairing NK cell clearance of HIV-infected targets. Therapeutic blockade of HLA-E: NKG2A interaction may yield benefit in HIV disease.


领域地球科学 ; 气候变化 ; 资源环境
收录类别SCI-E
WOS记录号WOS:000419324700073
WOS关键词C EXPRESSION ; RECEPTOR CD94/NKG2A ; DOWN-REGULATION ; INFECTED CELLS ; NK CELLS ; TRANSPLANTATION ; ASSOCIATION ; VARIANTS ; PROTEINS ; DISEASE
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
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引用统计
文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/197679
专题地球科学
资源环境科学
气候变化
作者单位1.Leidos Biomed Res Inc, Canc & Inflammat Program, Frederick Natl Lab Canc Res, Frederick, MD 21702 USA;
2.Ragon Inst Massachusetts Gen Hosp Massachusetts I, Cambridge, MA 02139 USA;
3.Univ KwaZulu Natal, Sch Lab Med & Med Sci, KwaZulu Natal Res Innovat & Sequencing Platform K, Durban, South Africa;
4.Ctr AIDS Programme Res South Africa CAPRISA, Durban, South Africa;
5.Univ Oxford, Nuffield Dept Med, Wellcome Trust Ctr Human Genet, Oxford, England;
6.Icahn Sch Med Mt Sinai, Dept Oncol Sci, Precis Immunol Inst, New York, NY 10029 USA;
7.NCI, Canc & Inflammat Program, Ctr Canc Res, NIH, Frederick, MD 21702 USA;
8.Leidos Biomed Res Inc, AIDS & Canc Virus Program, Frederick Natl Lab Canc Res, Frederick, MD 21702 USA;
9.Ecole Polytech Fed Lausanne, Sch Life Sci, Lausanne, Switzerland;
10.Swiss Inst Bioinformat, Lausanne, Switzerland;
11.Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA;
12.Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA;
13.NCI, Infect & Immunoepidemiol Branch, Div Canc Epidemiol & Genet, NIH, Rockville, MD 20850 USA;
14.Northwestern Univ, Div Infect Dis, Feinberg Sch Med, Chicago, IL 60611 USA;
15.Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA;
16.Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA;
17.San Francisco Dept Publ Hlth, HIV Res Sect, San Francisco, CA 94102 USA;
18.Vanderbilt Univ, Sch Med, Nashville, TN 37232 USA;
19.African Hlth Res Inst, Durban, South Africa;
20.Univ KwaZulu Natal, HIV Pathogenesis Programme, Doris Duke Med Res Inst, Nelson R Mandela Sch Med, Durban, South Africa;
21.Max Planck Inst Infect Biol, Berlin, Germany;
22.Univ Oxford, Dept Paediat, Oxford, England;
23.Stanford Univ, Dept Struct Biol, Stanford, CA 94305 USA;
24.Stanford Univ, Dept Microbiol & Immunol, Stanford, CA 94305 USA;
25.MIT, Inst Med & Engn Sci, Cambridge, MA 02139 USA;
26.Microsoft Res, Redmond, WA 98052 USA
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Ramsuran, Veron,39;u, Thumbi. Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells[J]. SCIENCE,2018,359(6371):86-90.
APA Ramsuran, Veron,&39;u, Thumbi.(2018).Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells.SCIENCE,359(6371),86-90.
MLA Ramsuran, Veron,et al."Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells".SCIENCE 359.6371(2018):86-90.
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