Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aan6490 |
A mitosis-specific and R loop-driven ATR pathway promotes faithful chromosome segregation | |
Kabeche, Lilian1; Nguyen, Hai Dang1; Buisson, Remi1; Zou, Lee1,2 | |
2018-01-05 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 359期号:6371页码:108-113 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | The ataxia telangiectasia mutated and Rad3-related (ATR) kinase is crucial for DNA damage and replication stress responses. Here, we describe an unexpected role of ATR in mitosis. Acute inhibition or degradation of ATR in mitosis induces whole-chromosome missegregation. The effect of ATR ablation is not due to altered cyclin-dependent kinase 1 (CDK1) activity, DNA damage responses, or unscheduled DNA synthesis but to loss of an ATR function at centromeres. In mitosis, ATR localizes to centromeres through Aurora A-regulated association with centromere protein F (CENP-F), allowing ATR to engage replication protein A (RPA)-coated centromeric R loops. As ATR is activated at centromeres, it stimulates Aurora B through Chk1, preventing formation of lagging chromosomes. Thus, a mitosis-specific and R loop-driven ATR pathway acts at centromeres to promote faithful chromosome segregation, revealing functions of R loops and ATR in suppressing chromosome instability. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000419324700077 |
WOS关键词 | REPLICATION STRESS ; AURORA-B ; CHECKPOINT ; PHOSPHORYLATION ; SITE ; TRANSCRIPTION ; INSTABILITY ; GENOME ; CHK1 ; RNA |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197672 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Harvard Med Sch, Massachusetts Gen Hosp Canc Ctr, Charlestown, MA 02129 USA; 2.Harvard Med Sch, Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA |
推荐引用方式 GB/T 7714 | Kabeche, Lilian,Nguyen, Hai Dang,Buisson, Remi,et al. A mitosis-specific and R loop-driven ATR pathway promotes faithful chromosome segregation[J]. SCIENCE,2018,359(6371):108-113. |
APA | Kabeche, Lilian,Nguyen, Hai Dang,Buisson, Remi,&Zou, Lee.(2018).A mitosis-specific and R loop-driven ATR pathway promotes faithful chromosome segregation.SCIENCE,359(6371),108-113. |
MLA | Kabeche, Lilian,et al."A mitosis-specific and R loop-driven ATR pathway promotes faithful chromosome segregation".SCIENCE 359.6371(2018):108-113. |
条目包含的文件 | 条目无相关文件。 |
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