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DOI | 10.1126/science.aao3290 |
The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients | |
Matson, Vyara1; Fessler, Jessica1; Bao, Riyue2,3; Chongsuwat, Tara4; Zha, Yuanyuan4; Alegre, Maria-Luisa4; Luke, Jason J.4; Gajewski, Thomas F.1,4 | |
2018-01-05 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 359期号:6371页码:104-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Anti-PD-1-based immunotherapy has had a major impact on cancer treatment but has only benefited a subset of patients. Among the variables that could contribute to interpatient heterogeneity is differential composition of the patients' microbiome, which has been shown to affect antitumor immunity and immunotherapy efficacy in preclinical mouse models. We analyzed baseline stool samples from metastatic melanoma patients before immunotherapy treatment, through an integration of 16S ribosomal RNA gene sequencing, metagenomic shotgun sequencing, and quantitative polymerase chain reaction for selected bacteria. A significant association was observed between commensal microbial composition and clinical response. Bacterial species more abundant in responders included Bifidobacterium longum, Collinsella aerofaciens, and Enterococcus faecium. Reconstitution of germ-free mice with fecal material from responding patients could lead to improved tumor control, augmented T cell responses, and greater efficacy of anti-PD-L1 therapy. Our results suggest that the commensal microbiome may have a mechanistic impact on antitumor immunity in human cancer patients. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000419324700076 |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197669 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Chicago, Dept Pathol, Chicago, IL 60637 USA; 2.Univ Chicago, Ctr Res Informat, Chicago, IL 60637 USA; 3.Univ Chicago, Dept Pediat, Chicago, IL 60637 USA; 4.Univ Chicago, Dept Med, Chicago, IL 60637 USA |
推荐引用方式 GB/T 7714 | Matson, Vyara,Fessler, Jessica,Bao, Riyue,et al. The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients[J]. SCIENCE,2018,359(6371):104-+. |
APA | Matson, Vyara.,Fessler, Jessica.,Bao, Riyue.,Chongsuwat, Tara.,Zha, Yuanyuan.,...&Gajewski, Thomas F..(2018).The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients.SCIENCE,359(6371),104-+. |
MLA | Matson, Vyara,et al."The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients".SCIENCE 359.6371(2018):104-+. |
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