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DOI | 10.1126/science.aao5654 |
Phase separation of a yeast prion protein promotes cellular fitness | |
Franzmann, Titus M.1; Jahnel, Marcus1,2; Pozniakovsky, Andrei1; Mahamid, Julia3; Holehouse, Alex S.4,5; Nuske, Elisabeth1; Richter, Doris1; Baumeister, Wolfgang6; Grill, Stephan W.1,2; Pappu, Rohit V.4,5; Hyman, Anthony A.1; Alberti, Simon1 | |
2018-01-05 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 359期号:6371页码:47-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Germany; USA |
英文摘要 | Despite the important role of prion domains in neurodegenerative disease, their physiological function has remained enigmatic. Previous work with yeast prions has defined prion domains as sequences that form self-propagating aggregates. Here, we uncovered an unexpected function of the canonical yeast prion protein Sup35. In stressed conditions, Sup35 formed protective gels via pH-regulated liquid-like phase separation followed by gelation. Phase separation was mediated by the N-terminal prion domain and regulated by the adjacent pH sensor domain. Phase separation promoted yeast cell survival by rescuing the essential Sup35 translation factor from stress-induced damage. Thus, prion-like domains represent conserved environmental stress sensors that facilitate rapid adaptation in unstable environments by modifying protein phase behavior. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000419324700063 |
WOS关键词 | STRESS ; SUP35 ; PSI+ ; URE3 ; GRANULES ; DOMAINS ; DETERMINANT ; PREDICTION ; FEATURES ; REGIONS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197667 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Max Planck Inst Mol Cell Biol & Genet, Pfotenhauerstr 108, D-01307 Dresden, Germany; 2.Tech Univ Dresden, Biotec, Tatzberg 47-48, D-01307 Dresden, Germany; 3.European Mol Biol Lab, Meyerhofstr 1, D-69117 Heidelberg, Germany; 4.Washington Univ St Louis, Dept Biomed Engn, St Louis, MO USA; 5.Washington Univ St Louis, Ctr Biol Syst Engn, St Louis, MO USA; 6.Max Planck Inst Biochem, Dept Mol Struct Biol, Klopferspitz 18, D-82152 Martinsried, Germany |
推荐引用方式 GB/T 7714 | Franzmann, Titus M.,Jahnel, Marcus,Pozniakovsky, Andrei,et al. Phase separation of a yeast prion protein promotes cellular fitness[J]. SCIENCE,2018,359(6371):47-+. |
APA | Franzmann, Titus M..,Jahnel, Marcus.,Pozniakovsky, Andrei.,Mahamid, Julia.,Holehouse, Alex S..,...&Alberti, Simon.(2018).Phase separation of a yeast prion protein promotes cellular fitness.SCIENCE,359(6371),47-+. |
MLA | Franzmann, Titus M.,et al."Phase separation of a yeast prion protein promotes cellular fitness".SCIENCE 359.6371(2018):47-+. |
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