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DOI | 10.1126/science.aao7294 |
Variation in the AvrSr35 gene determines Sr35 resistance against wheat stem rust race Ug99 | |
Salcedo, Andres1; Rutter, William1,9; Wang, Shichen1,10; Akhunova, Alina2; Bolus, Stephen3; Chao, Shiaoman4; Anderson, Nickolas1; De Soto, Monica Fernandez2; Rouse, Matthew5,6; Szabo, Les5,6; Bowden, Robert L.7; Dubcovsky, Jorge3,8; Akhunov, Eduard1 | |
2017-12-22 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 358期号:6370页码:1604-1606 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Puccinia graminis f. sp. tritici (Pgt) causes wheat stem rust, a devastating fungal disease. The Sr35 resistance gene confers immunity against this pathogen's most virulent races, including Ug99. We used comparative whole-genome sequencing of chemically mutagenized and natural Pgt isolates to identify a fungal gene named AvrSr35 that is required for Sr35 avirulence. The AvrSr35 gene encodes a secreted protein capable of interacting with Sr35 and triggering the immune response. We show that the origin of Pgt isolates virulent on Sr35 is associated with the nonfunctionalization of the AvrSr35 gene by the insertion of a mobile element. The discovery of AvrSr35 provides a new tool for Pgt surveillance, identification of host susceptibility targets, and characterization of the molecular determinants of immunity in wheat. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000418448000062 |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197604 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Kansas State Univ, Dept Plant Pathol, Throckmorton Hall, Manhattan, KS 66506 USA; 2.Kansas State Univ, Integrated Genom Facil, Manhattan, KS 66506 USA; 3.Univ Calif Davis, Dept Plant Sci, Davis, CA 95616 USA; 4.USDA ARS, Cereal Crops Res Unit, Fargo, ND 58102 USA; 5.USDA ARS, Cereal Dis Lab, St Paul, MN 55108 USA; 6.Univ Minnesota, Dept Plant Pathol, St Paul, MN 55108 USA; 7.USDA ARS, Hard Winter Wheat Genet Res Unit, Manhattan, KS 66506 USA; 8.HHMI, Chevy Chase, MD 20815 USA; 9.USDA ARS, US Vegetable Lab, Charleston, SC 29414 USA; 10.Texas A&M Univ, Texas A&M Engn Expt Stn, AgriLife Ctr Bioinformat & Genom Syst Engn, College Stn, TX 77845 USA |
推荐引用方式 GB/T 7714 | Salcedo, Andres,Rutter, William,Wang, Shichen,et al. Variation in the AvrSr35 gene determines Sr35 resistance against wheat stem rust race Ug99[J]. SCIENCE,2017,358(6370):1604-1606. |
APA | Salcedo, Andres.,Rutter, William.,Wang, Shichen.,Akhunova, Alina.,Bolus, Stephen.,...&Akhunov, Eduard.(2017).Variation in the AvrSr35 gene determines Sr35 resistance against wheat stem rust race Ug99.SCIENCE,358(6370),1604-1606. |
MLA | Salcedo, Andres,et al."Variation in the AvrSr35 gene determines Sr35 resistance against wheat stem rust race Ug99".SCIENCE 358.6370(2017):1604-1606. |
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