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DOI | 10.1126/science.aao4165 |
Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation | |
Aillaud, Chrystelle1,2; Bosc, Christophe1,2; Peris, Leticia1,2; Bosson, Anouk1,2; Heemeryck, Pierre1,2; Van Dijk, Juliette2,3,4; Le Friec, Julien1,2; Boulan, Benoit1,2; Vossier, Frederique1,2; Sanman, Laura E.5; Syed, Salahuddin5; Amara, Neri5; Coute, Yohann6; Lafanechere, Laurence7; Denarier, Eric1,2,8; Delphin, Christian1,2; Pelletier, Laurent1,2; Humbert, Sandrine1,2; Bogyo, Matthew5; Andrieux, Annie1,2,8; Rogowski, Krzysztof3; Moutin, Marie-Jo1,2 | |
2017-12-15 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 358期号:6369页码:1448-1452 |
文章类型 | Article |
语种 | 英语 |
国家 | France; USA |
英文摘要 | Reversible detyrosination of alpha-tubulin is crucial to microtubule dynamics and functions, and defects have been implicated in cancer, brain disorganization, and cardiomyopathies. The identity of the tubulin tyrosine carboxypeptidase (TCP) responsible for detyrosination has remained unclear. We used chemical proteomics with a potent irreversible inhibitor to show that the major brain TCP is a complex of vasohibin-1 (VASH1) with the small vasohibin binding protein (SVBP). VASH1 and its homolog VASH2, when complexed with SVBP, exhibited robust and specific Tyr/Phe carboxypeptidase activity on microtubules. Knockdown of vasohibins or SVBP and/or inhibitor addition in cultured neurons reduced detyrosinated alpha-tubulin levels and caused severe differentiation defects. Furthermore, knockdown of vasohibins disrupted neuronal migration in developing mouse neocortex. Thus, vasohibin/SVBP complexes represent long-sought TCP enzymes. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000417918500045 |
WOS关键词 | POSTTRANSLATIONAL MODIFICATIONS ; MICROTUBULE DETYROSINATION ; TYROSINATION ; INHIBITION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197556 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Grenoble Alpes, GIN, F-38000 Grenoble, France; 2.INSERM, U1216, F-38000 Grenoble, France; 3.Univ Montpellier, CNRS, IGH, UMR9002, F-34000 Montpellier, France; 4.Univ Montpellier, CNRS, CRBM, UMR5237, F-34000 Montpellier, France; 5.Stanford Univ, Dept Pathol, Sch Med, Stanford, CA 94305 USA; 6.Univ Grenoble Alpes, CEA, INSERM, Inst Biosci & Biotechnol Grenoble BIG,Lab Biol Gr, F-38000 Grenoble, France; 7.Univ Grenoble Alpes, CNRS UMR 5309, Inst Adv Biosci, INSFRM,U1209,Team Regulat & Pharmacol Cytoskeleto, F-38000 Grenoble, France; 8.CEA, BIG Physiopathol Cytosquelette, F-38000 Grenoble, France |
推荐引用方式 GB/T 7714 | Aillaud, Chrystelle,Bosc, Christophe,Peris, Leticia,et al. Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation[J]. SCIENCE,2017,358(6369):1448-1452. |
APA | Aillaud, Chrystelle.,Bosc, Christophe.,Peris, Leticia.,Bosson, Anouk.,Heemeryck, Pierre.,...&Moutin, Marie-Jo.(2017).Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation.SCIENCE,358(6369),1448-1452. |
MLA | Aillaud, Chrystelle,et al."Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation".SCIENCE 358.6369(2017):1448-1452. |
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