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DOI | 10.1126/science.aap8809 |
Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex | |
Nowakowski, Tomasz J.1,2,3; Bhaduri, Aparna1,2; Pollen, Alex A.1,2; Alvarado, Beatriz1,2; Mostajo-Radji, Mohammed A.1,2; Di Lullo, Elizabeth1,2; Haeussler, Maximilian4; Sandoval-Espinosa, Carmen1,2; Liu, Siyuan John5; Velmeshev, Dmitry1,2; Ounadjela, Johain Ryad2,3; Shuga, Joe6; Wang, Xiaohui6; Lim, Daniel A.2,5; West, Jay A.6; Leyrat, Anne A.6; Kent, W. James4; Kriegstein, Arnold R.1,2,3 | |
2017-12-08 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 358期号:6368页码:1318-1323 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Systematic analyses of spatiotemporal gene expression trajectories during organogenesis have been challenging because diverse cell types at different stages of maturation and differentiation coexist in the emerging tissues. We identified discrete cell types as well as temporally and spatially restricted trajectories of radial glia maturation and neurogenesis in developing human telencephalon. These lineage-specific trajectories reveal the expression of neurogenic transcription factors in early radial glia and enriched activation of mammalian target of rapamycin signaling in outer radial glia. Across cortical areas, modest transcriptional differences among radial glia cascade into robust typological distinctions among maturing neurons. Together, our results support a mixed model of topographical, typological, and temporal hierarchies governing cell-type diversity in the developing human telencephalon, including distinct excitatory lineages emerging in rostral and caudal cerebral cortex. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000417254700062 |
WOS关键词 | HUMAN CEREBRAL-CORTEX ; HUMAN BRAIN ; CORTICAL AREAS ; RADIAL GLIA ; CELL-TYPES ; NEOCORTEX ; DIVERSITY ; NEURONS ; ORIGIN |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197488 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.UCSF, Dept Neurol, San Francisco, CA 94143 USA; 2.UCSF, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, San Francisco, CA 94143 USA; 3.UCSF, Dept Anat, San Francisco, CA 94143 USA; 4.Univ Calif Santa Cruz, Genom Inst, Santa Cruz, CA 95064 USA; 5.UCSF, Dept Neurosurg, Santa Cruz, CA 95064 USA; 6.Fluidigm, New Technol, San Francisco, CA USA |
推荐引用方式 GB/T 7714 | Nowakowski, Tomasz J.,Bhaduri, Aparna,Pollen, Alex A.,et al. Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex[J]. SCIENCE,2017,358(6368):1318-1323. |
APA | Nowakowski, Tomasz J..,Bhaduri, Aparna.,Pollen, Alex A..,Alvarado, Beatriz.,Mostajo-Radji, Mohammed A..,...&Kriegstein, Arnold R..(2017).Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex.SCIENCE,358(6368),1318-1323. |
MLA | Nowakowski, Tomasz J.,et al."Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex".SCIENCE 358.6368(2017):1318-1323. |
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